The Acid Gate in the Lysosome.

Vacuolar Proton-Translocating ATPases / metabolism Autophagy / genetics Protons Acids / metabolism Lysosomes / metabolism Hydrogen-Ion Concentration
H+ leak Proton channel TMEM175 acidification lysosome

Journal

Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188

Informations de publication

Date de publication:
04 2023
Historique:
pubmed: 20 9 2022
medline: 14 3 2023
entrez: 19 9 2022
Statut: ppublish

Résumé

The acidic environment within lysosomes is maintained within a narrow pH range (pH 4.5-5.0) optimal for digesting autophagic cargo macromolecules so that the resulting building block metabolites can be reused. This pH homeostasis is a consequence of proton influx produced by a V-type H

Identifiants

DOI: 10.1080/15548627.2022.2125629 PMID: 36120744 PMC: PMC10012942
pubmed: 36120744
doi: 10.1080/15548627.2022.2125629
pmc: PMC10012942
doi:

Substances chimiques

Vacuolar Proton-Translocating ATPases EC 3.6.1.-
Protons 0
Acids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1368-1370

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK115474
Pays : United States

Références

Cell. 2022 Jun 23;185(13):2292-2308.e20
pubmed: 35750034

Auteurs

Meiqin Hu (M)

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI, USA.
Liangzhu Laboratory & Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, China.
ORCID: 0000-0002-3953-5868

Jingzhi Chen (J)

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
Liangzhu Laboratory & Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, China.
ORCID: 0000-0002-7884-3177

Siyu Liu (S)

Liangzhu Laboratory & Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, China.
ORCID: 0000-0003-3295-213X

Haoxing Xu (H)

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI, USA.
Liangzhu Laboratory & Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, China.
ORCID: 0000-0003-3561-4654

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Proton-Translocating ATPases › Vacuolar Proton-Translocating ATPases › The Acid Gate in the Lysosome.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › The Acid Gate in the Lysosome.
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › The Acid Gate in the Lysosome.
questionsmedicales.fr › Produits chimiques inorganiques › Acides › The Acid Gate in the Lysosome.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › The Acid Gate in the Lysosome.
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › The Acid Gate in the Lysosome.