Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (
Animals
Acetylcholinesterase
/ metabolism
Anti-Bacterial Agents
/ pharmacology
Antifungal Agents
/ pharmacology
Antioxidants
/ adverse effects
Brain
/ metabolism
Cholinergic Agents
/ pharmacology
Galantamine
/ pharmacology
Glucose
/ pharmacology
Hypnotics and Sedatives
/ pharmacology
Imipramine
/ pharmacology
Iridoid Glucosides
/ pharmacology
Maze Learning
Memory Disorders
/ chemically induced
Oxidative Stress
Scopolamine
/ adverse effects
Sugars
Zebrafish
/ metabolism
Schenkia spicata
cholinergic function
memory
oxidative stress
scopolamine
sweroside
zebrafish
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Sep 2022
11 Sep 2022
Historique:
received:
02
08
2022
revised:
26
08
2022
accepted:
07
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Sweroside is a secoiridoid glycoside and belongs to a large group of naturally occurring monoterpenes with glucose sugar attached to C-1 in the pyran ring. Sweroside can promote different biological activities such as antifungal, antibacterial, hepatoprotective, gastroprotective, sedative and antitumor, antioxidant, and neuroprotective activities. Zebrafish were given sweroside (12.79, 8.35, and 13.95 nM) by immersion once daily for 8 days, along with scopolamine (Sco, 100 μM) 30 min before the initiation of the behavioral testing to cause anxiety and memory loss. Employing the novel tank diving test (NTT), the Y-maze, and the novel object recognition test (NOR), anxiety-like reactions and memory-related behaviors were assessed. The following seven groups (
Identifiants
pubmed: 36144637
pii: molecules27185901
doi: 10.3390/molecules27185901
pmc: PMC9502219
pii:
doi:
Substances chimiques
Acetylcholinesterase
EC 3.1.1.7
Anti-Bacterial Agents
0
Antifungal Agents
0
Antioxidants
0
Cholinergic Agents
0
Galantamine
0D3Q044KCA
Glucose
IY9XDZ35W2
Hypnotics and Sedatives
0
Imipramine
OGG85SX4E4
Iridoid Glucosides
0
Scopolamine
DL48G20X8X
Sugars
0
sweroside
I3YG76417O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : This research received funding from the Doctoral School of Biology, Alexandru Ioan Cuza Uni-versity of Iasi, Romania.
ID : 0
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