Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.

Clostridium histolyticum Collagenases / metabolism Diphosphonates Matrix Metalloproteinase Inhibitors Microbial Collagenase

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 10 2022
Historique:
pubmed: 27 9 2022
medline: 15 10 2022
entrez: 26 9 2022
Statut: ppublish

Résumé

In view of the worldwide antimicrobial resistance (AMR) threat, new bacterial targets and anti-infective agents are needed. Since important roles in bacterial pathogenesis have been demonstrated for the collagenase H and G (ColH and ColG) from

Identifiants

DOI: 10.1021/acs.jmedchem.2c00785 PMID: 36154055 PMC: PMC9574867
pubmed: 36154055
doi: 10.1021/acs.jmedchem.2c00785
pmc: PMC9574867
doi:

Substances chimiques

Diphosphonates 0
Matrix Metalloproteinase Inhibitors 0
Collagenases EC 3.4.24.-
Microbial Collagenase EC 3.4.24.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12933-12955

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Auteurs

Alaa Alhayek (A)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Department of Pharmacy, Saarland University, Campus Building C2. 3, 66123 Saarbrücken, Germany.

Ahmed S Abdelsamie (AS)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Department of Chemistry of Natural and Microbial Products, Institute of Pharmaceutical and Drug Industries Research, National Research Centre, El-Buhouth St., Dokki, 12622 Cairo, Egypt.

Esther Schönauer (E)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Virgyl Camberlein (V)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.

Evelyn Hutterer (E)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.
ORCID: 0000-0001-8622-4758

Gernot Posselt (G)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Jamil Serwanja (J)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Constantin Blöchl (C)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Christian G Huber (CG)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Jörg Haupenthal (J)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.

Hans Brandstetter (H)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Silja Wessler (S)

Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria.

Anna K H Hirsch (AKH)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Department of Pharmacy, Saarland University, Campus Building C2. 3, 66123 Saarbrücken, Germany.
ORCID: 0000-0001-8734-4663

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bactéries à Gram positif formant des endospores › Clostridium › Clostridium histolyticum › Discovery and Characterization of Synthesized...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases › Metalloendopeptidases › Collagenases › Discovery and Characterization of Synthesized...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Discovery and Characterization of Synthesized...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs de métalloprotéinases matricielles › Discovery and Characterization of Synthesized...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases › Metalloendopeptidases › Collagenases › Microbial collagenase › Discovery and Characterization of Synthesized...