A mechanism for oxidative damage repair at gene regulatory elements.

Cell Cycle Proteins / metabolism Chromatin / genetics DNA Damage DNA Repair Genes Genetic Complementation Test Mitosis Mutation Oxidative Stress / genetics Phosphoric Diester Hydrolases / metabolism Poly ADP Ribosylation Promoter Regions, Genetic / genetics RNA / biosynthesis RNA Polymerase II / metabolism Spindle Apparatus / metabolism Transcription Initiation Site

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 06 03 2020
accepted: 09 08 2022
entrez: 28 9 2022
pubmed: 29 9 2022
medline: 1 10 2022
Statut: ppublish

Résumé

Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation

Identifiants

DOI: 10.1038/s41586-022-05217-8 PMID: 36171374
pubmed: 36171374
doi: 10.1038/s41586-022-05217-8
pii: 10.1038/s41586-022-05217-8
doi:

Substances chimiques

Cell Cycle Proteins 0
Chromatin 0
RNA 63231-63-0
RNA Polymerase II EC 2.7.7.-
Phosphoric Diester Hydrolases EC 3.1.4.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1038-1047

Subventions

Organisme : Wellcome Trust
ID : 103844
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Swagat Ray (S)

School of Biosciences, University of Sheffield, Sheffield, UK.
The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.
School of Life and Environmental Sciences, Department of Life Sciences, University of Lincoln, Lincoln, UK.

Arwa A Abugable (AA)

School of Biosciences, University of Sheffield, Sheffield, UK.
The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.

Jacob Parker (J)

School of Biosciences, University of Sheffield, Sheffield, UK.
Center for Advanced Parkinson Research, Harvard Medical School, Boston, MA, USA.

Kirsty Liversidge (K)

School of Biosciences, University of Sheffield, Sheffield, UK.

Nelma M Palminha (NM)

School of Biosciences, University of Sheffield, Sheffield, UK.
The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.

Chunyan Liao (C)

School of Biosciences, University of Sheffield, Sheffield, UK.
The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.

Adelina E Acosta-Martin (AE)

biOMICS Facility, Faculty of Science Mass Spectrometry Centre, University of Sheffield, Sheffield, UK.

Cleide D S Souza (CDS)

School of Biosciences, University of Sheffield, Sheffield, UK.
Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, UK.

Mateusz Jurga (M)

Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK.

Ian Sudbery (I)

School of Biosciences, University of Sheffield, Sheffield, UK.

Sherif F El-Khamisy (SF)

School of Biosciences, University of Sheffield, Sheffield, UK. s.el-khamisy@sheffield.ac.uk.
The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK. s.el-khamisy@sheffield.ac.uk.
Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK. s.el-khamisy@sheffield.ac.uk.
ORCID: 0000-0003-2721-7763

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Croisements génétiques › Test de complémentation › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphodiesterases › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › ADP-Ribosylation › Poly(ADP-ribosylation) › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Appareil du fuseau › A mechanism for oxidative damage repair at...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Site d'initiation de la transcription › A mechanism for oxidative damage repair at...