High tumor amplification burden is associated with
TP53
amplifications
cancer genes
next-generation sequencing
Journal
Cancer biology & therapy
ISSN: 1555-8576
Titre abrégé: Cancer Biol Ther
Pays: United States
ID NLM: 101137842
Informations de publication
Date de publication:
31 12 2022
31 12 2022
Historique:
entrez:
28
9
2022
pubmed:
29
9
2022
medline:
1
10
2022
Statut:
ppublish
Résumé
Next-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications - "amplificators". We sought to understand the molecular correlates of high tumor amplification burden in a pan-cancer context. Using both national registries and a single-institution dataset, our results demonstrate that cancers with
Identifiants
pubmed: 36171565
doi: 10.1080/15384047.2022.2128608
pmc: PMC9542347
doi:
Substances chimiques
Biomarkers, Tumor
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Subventions
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
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