Ion mobility-mass spectrometry to extend analytical performance in the determination of ergot alkaloids in cereal samples.

Edible Grain / chemistry Ergot Alkaloids / analysis Ergotamines / analysis Ion Mobility Spectrometry / methods Mass Spectrometry / methods
Cereal samples Collision cross section Ergot alkaloids Ion mobility-mass spectrometry Travelling wave ion mobility spectrometry

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
25 Oct 2022
Historique:
received: 28 07 2022
revised: 30 08 2022
accepted: 12 09 2022
pubmed: 30 9 2022
medline: 12 10 2022
entrez: 29 9 2022
Statut: ppublish

Résumé

This work evaluates the potential of ion mobility spectrometry (IMS) to improve the analytical performance of current liquid chromatography-mass spectrometry (LC-MS) workflows applied to the determination of ergot alkaloids (EAs) in cereal samples. Collision cross section (CCS) values for EA epimers are reported for the first time to contribute to their unambiguous identification. Additionally, CCS values have been inter-laboratory cross-validated and compared with CCS values predicted by machine-learning models. Slight differences were observed in terms of CCS values for ergotamine, ergosine and ergocristine and their corresponding epimers (from 3.3 to 4%), being sufficient to achieve a satisfactory peak-to-peak resolution for their unequivocal identification. A LC-travelling wave ion mobility (TWIM)-MS method has been developed for the analysis of EAs in barley and wheat samples. Signal-to-noise ratio (S/N) was improved between 2.5 and 4-fold compared to the analog LC-TOF-MS method. The quality of the extracted ion chromatograms was also improved by using IMS.

Identifiants

DOI: 10.1016/j.chroma.2022.463502 PMID: 36174373
pubmed: 36174373
pii: S0021-9673(22)00694-X
doi: 10.1016/j.chroma.2022.463502
pii:
doi:

Substances chimiques

Ergot Alkaloids 0
Ergotamines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

463502

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Laura Carbonell-Rozas (L)

Oniris, INRAE, LABERCA, 44300 Nantes, France; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.

Maykel Hernández-Mesa (M)

Oniris, INRAE, LABERCA, 44300 Nantes, France; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain. Electronic address: maykelhm@ugr.es.

Laura Righetti (L)

Department of Food and Drug, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.

Fabrice Monteau (F)

Oniris, INRAE, LABERCA, 44300 Nantes, France.

Francisco J Lara (FJ)

Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.

Laura Gámiz-Gracia (L)

Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.

Bruno Le Bizec (BL)

Oniris, INRAE, LABERCA, 44300 Nantes, France.

Chiara Dall'Asta (C)

Department of Food and Drug, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.

Ana M García-Campaña (AM)

Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.

Gaud Dervilly (G)

Oniris, INRAE, LABERCA, 44300 Nantes, France.

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Classifications MeSH

questionsmedicales.fr › Aliments et boissons › Aliments › Graines › Grains comestibles › Ion mobility-mass spectrometry to extend...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes de l'ergot › Ion mobility-mass spectrometry to extend...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Ergotamines › Ion mobility-mass spectrometry to extend...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrométrie de mobilité ionique › Ion mobility-mass spectrometry to extend...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Ion mobility-mass spectrometry to extend...