Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy.

Brain / metabolism Cognitive Behavioral Therapy Dopamine / metabolism Dopamine Plasma Membrane Transport Proteins / metabolism Escitalopram Humans Phobia, Social / drug therapy Serotonin / metabolism Serotonin Plasma Membrane Transport Proteins / metabolism Selective Serotonin Reuptake Inhibitors / pharmacology

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
07 10 2022
Historique:
received: 04 05 2022
accepted: 13 09 2022
revised: 08 09 2022
entrez: 6 10 2022
pubmed: 7 10 2022
medline: 12 10 2022
Statut: epublish

Résumé

Selective serotonin reuptake inhibitors (SSRIs) and internet-based cognitive behavioral therapy (ICBT) are recommended treatments of social anxiety disorder (SAD), and often combined, but their effects on monoaminergic signaling are not well understood. In this multi-tracer positron emission tomography (PET) study, 24 patients with SAD were randomized to treatment with escitalopram+ICBT or placebo+ICBT under double-blind conditions. Before and after 9 weeks of treatment, patients were examined with positron emission tomography and the radioligands [

Identifiants

DOI: 10.1038/s41398-022-02187-3 PMID: 36202797 PMC: PMC9537299
pubmed: 36202797
doi: 10.1038/s41398-022-02187-3
pii: 10.1038/s41398-022-02187-3
pmc: PMC9537299
doi:

Substances chimiques

Dopamine Plasma Membrane Transport Proteins 0
Serotonin Plasma Membrane Transport Proteins 0
Serotonin Uptake Inhibitors 0
Serotonin 333DO1RDJY
Escitalopram 4O4S742ANY
Dopamine VTD58H1Z2X

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

436

Informations de copyright

© 2022. The Author(s).

Références

Am J Geriatr Psychiatry. 2011 Dec;19(12):1016-25
pubmed: 21841458
Prog Brain Res. 2008;172:3-6
pubmed: 18772025
J Consult Clin Psychol. 2006 Aug;74(4):677-86
pubmed: 16881775
Arch Gen Psychiatry. 2002 May;59(5):425-33
pubmed: 11982446
Prog Brain Res. 2008;172:7-44
pubmed: 18772026
Hum Brain Mapp. 2003 Aug;19(4):224-47
pubmed: 12874777
Metab Brain Dis. 2012 Jun;27(2):151-8
pubmed: 22350963
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
BJPsych Open. 2018 May 11;4(3):157-159
pubmed: 29922481
Depress Anxiety. 2000;11(1):45-7
pubmed: 10723636
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt C):291-294
pubmed: 28342944
Psychopharmacology (Berl). 2007 Sep;193(4):539-45
pubmed: 17497139
Neuropsychopharmacology. 2003 Feb;28(2):413-20
pubmed: 12589396
Pharmacol Ther. 1995 Mar;65(3):319-95
pubmed: 7644567
J Neuroimaging. 2013 Oct;23(4):469-76
pubmed: 23751132
Psychogeriatrics. 2013 Sep;13(3):189-95
pubmed: 25913769
Neuroscience. 2014 Dec 12;282:13-22
pubmed: 24463000
Br J Psychiatry. 2016 Sep;209(3):229-35
pubmed: 27340112
Eur Neuropsychopharmacol. 2017 May;27(5):462-469
pubmed: 28377075
eNeuro. 2017 Feb 15;4(1):
pubmed: 28275709
Encephale. 2018 Jun;44(3):264-273
pubmed: 29801770
Neuron. 2005 Apr 7;46(1):65-74
pubmed: 15820694
J Psychopharmacol. 2010 May;24(5):709-16
pubmed: 18838500
Biol Psychiatry. 2005 Jul 15;58(2):132-42
pubmed: 16038684
Neuropharmacology. 2008 Nov;55(6):1023-8
pubmed: 18634807
Br J Psychiatry. 2009 Nov;195(5):440-7
pubmed: 19880935
JAMA Psychiatry. 2013 Oct;70(10):1048-56
pubmed: 23945981
Am J Psychiatry. 2004 May;161(5):826-35
pubmed: 15121647
PLoS One. 2011 Mar 25;6(3):e18001
pubmed: 21483704
Eur J Pharmacol. 2010 Nov 25;647(1-3):90-6
pubmed: 20816814
Depress Anxiety. 1998;7(3):126-9
pubmed: 9656093
Neurosci Lett. 2006 Jun 19;401(1-2):49-54
pubmed: 16638624
Biol Psychiatry. 2007 May 1;61(9):1081-9
pubmed: 16979141
Transl Psychiatry. 2021 May 10;11(1):264
pubmed: 33972499
N Engl J Med. 2017 Jun 8;376(23):2255-2264
pubmed: 28591542
Eur Neuropsychopharmacol. 2015 Jun;25(6):873-81
pubmed: 25819144
Neuropsychologia. 2013 Sep;51(11):2062-9
pubmed: 23911778
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Psychopharmacology (Berl). 2002 Dec;164(4):341-8
pubmed: 12457263
J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40
pubmed: 8784228
Psychopharmacology (Berl). 2006 Dec;189(2):145-53
pubmed: 17033844
Pharmacol Ther. 2009 Jan;121(1):89-99
pubmed: 19022290
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
Depress Anxiety. 2009;26(5):411-8
pubmed: 19180583
Am J Psychiatry. 1997 Feb;154(2):239-42
pubmed: 9016274
Neurochem Int. 2005 Oct;47(5):350-61
pubmed: 15979209
Neuropharmacology. 2012 Jan;62(1):115-24
pubmed: 21903105
Biol Psychiatry. 2013 Feb 15;73(4):300-1
pubmed: 23351889
Am J Psychiatry. 2000 Mar;157(3):457-9
pubmed: 10698826
Mol Psychiatry. 2021 Aug;26(8):3970-3979
pubmed: 31822819
Eur Neuropsychopharmacol. 2016 Nov;26(11):1775-1783
pubmed: 27642077
Arch Gen Psychiatry. 2005 Jun;62(6):629-40
pubmed: 15939840
JAMA Psychiatry. 2015 Aug;72(8):794-802
pubmed: 26083190
J Psychiatry Neurosci. 2009 May;34(3):223-9
pubmed: 19448853
Br J Psychiatry. 2007 Feb;190:123-8
pubmed: 17267928
J Neural Transm (Vienna). 2006 May;113(5):659-70
pubmed: 16465456
Lancet Psychiatry. 2014 Oct;1(5):368-76
pubmed: 26361000
Biol Psychiatry. 2006 Feb 15;59(4):301-8
pubmed: 16197922
Soc Psychiatry Psychiatr Epidemiol. 1999 Aug;34(8):416-24
pubmed: 10501711
Neuron. 2005 Jun 16;46(6):957-69
pubmed: 15953423
Neuroimage. 1997 Nov;6(4):279-87
pubmed: 9417971
J Nucl Med. 2008 May;49(5):757-63
pubmed: 18413401
Psychiatry Res. 2013 Dec 30;214(3):229-37
pubmed: 24064198
J Neurol Sci. 2011 Nov 15;310(1-2):53-7
pubmed: 21783205
Transl Psychiatry. 2021 Nov 3;11(1):559
pubmed: 34732695
Pharmacol Ther. 2000 Jan;85(1):11-28
pubmed: 10674711
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:83-91
pubmed: 23665375
Cogn Behav Ther. 2018 Jan;47(1):1-18
pubmed: 29215315
Psychol Med. 2001 Aug;31(6):1025-35
pubmed: 11513370
Lancet. 2008 Mar 29;371(9618):1115-25
pubmed: 18374843
JAMA Psychiatry. 2013 Jan;70(1):87-97
pubmed: 22945462
Eur Neuropsychopharmacol. 2005 Oct;15(5):521-4
pubmed: 16139170
Pharmacogenet Genomics. 2009 Jan;19(1):67-76
pubmed: 18987562
Psychiatry Res. 2014 Aug 30;223(2):164-70
pubmed: 24916155
J Nucl Med. 2007 Mar;48(3):359-66
pubmed: 17332612
Transl Psychiatry. 2012 May 22;2:e120
pubmed: 22832965
Neuroimage. 2005 Feb 15;24(4):969-79
pubmed: 15670674
Transl Psychiatry. 2014 Aug 05;4:e420
pubmed: 25093598

Auteurs

Olof Hjorth (O)

Department of Psychology, Uppsala University, Uppsala, Sweden. olof.hjorth@psyk.uu.se.
ORCID: 0000-0002-4784-5196

Andreas Frick (A)

Department of Psychology, Uppsala University, Uppsala, Sweden.
The Beijer Laboratory, Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-2516-9075

Malin Gingnell (M)

Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.

Jonas Engman (J)

Department of Psychology, Uppsala University, Uppsala, Sweden.

Johannes Björkstrand (J)

Department of Psychology, Lund University, Lund, Sweden.

Vanda Faria (V)

Center for Pain and the Brain, Department of Anesthesiology Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

Iman Alaie (I)

Department of Medical Sciences, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden.

Per Carlbring (P)

Department of Psychology, Stockholm University, Stockholm, Sweden.
ORCID: 0000-0002-2172-8813

Gerhard Andersson (G)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Behavioural Sciences and Learning, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

My Jonasson (M)

Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.

Mark Lubberink (M)

Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.

Gunnar Antoni (G)

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Margareta Reis (M)

Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Kurt Wahlstedt (K)

Department of Psychology, Uppsala University, Uppsala, Sweden.

Mats Fredrikson (M)

Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Tomas Furmark (T)

Department of Psychology, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0001-6821-9058

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Serotonin and dopamine transporter...
questionsmedicales.fr › Disciplines et activités comportementales › Psychothérapie › Thérapie comportementale › Thérapie cognitive › Serotonin and dopamine transporter...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Serotonin and dopamine transporter...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la dopamine › Serotonin and dopamine transporter...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzofuranes › Escitalopram › Serotonin and dopamine transporter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Serotonin and dopamine transporter...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Troubles phobiques › Phobie sociale › Serotonin and dopamine transporter...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Serotonin and dopamine transporter...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la sérotonine › Serotonin and dopamine transporter...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents sérotoninergiques › Inhibiteurs sélectifs de la recapture de la sérotonine › Serotonin and dopamine transporter...