Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 10 2022
07 10 2022
Historique:
received:
27
07
2022
accepted:
21
09
2022
entrez:
7
10
2022
pubmed:
8
10
2022
medline:
12
10
2022
Statut:
epublish
Résumé
Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling to conduct a GWAS of the new Genetics of Opioid Addiction Consortium (GENOA) data together with published studies (Psychiatric Genomics Consortium, Million Veteran Program, and Partners Health), comprising 23,367 cases and effective sample size of 88,114 individuals of European ancestry. Genetic correlations among the various OA phenotypes were uniformly high (r
Identifiants
pubmed: 36207451
doi: 10.1038/s41598-022-21003-y
pii: 10.1038/s41598-022-21003-y
pmc: PMC9546890
doi:
Substances chimiques
OPRM1 protein, human
0
Receptors, Opioid, mu
0
Furin
EC 3.4.21.75
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
16873Subventions
Organisme : NIDA NIH HHS
ID : R33DA027486
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA044014
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAAA NIH HHS
ID : U10AA008401
Pays : United States
Organisme : NIDA NIH HHS
ID : R01DA038632
Pays : United States
Organisme : NIDA NIH HHS
ID : R01DA044014
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1RR024143
Pays : United States
Organisme : NIDA NIH HHS
ID : K01DA036751
Pays : United States
Organisme : NIDA NIH HHS
ID : R01DA04401
Pays : United States
Informations de copyright
© 2022. The Author(s).
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