Left atrial dysfunction as the major driver of heart failure with preserved ejection fraction syndrome.
diastolic dysfunction
echocardiography
heart failure with preserved ejection fraction
left atrial dysfunction
Journal
Journal of clinical ultrasound : JCU
ISSN: 1097-0096
Titre abrégé: J Clin Ultrasound
Pays: United States
ID NLM: 0401663
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
revised:
21
07
2022
received:
30
06
2022
accepted:
23
07
2022
entrez:
11
10
2022
pubmed:
12
10
2022
medline:
13
10
2022
Statut:
ppublish
Résumé
Left atrial (LA) dysfunction seems to play a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), is associated with disease severity and poor outcomes and potentially impacts management. Identifying LA myopathy can help guide tailored therapy for HFpEF. Echocardiography allows the accurate measurement of atrial size and function, where LA strain appears to be a sensitive measure of intrinsic LA myopathy. Several therapies and devices that decompress of left atrium are being tested for HFpEF. Further investigation is required to understand the specific atrial effects of statins, mineralocorticoid receptor antagonists, and other therapies.
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Mineralocorticoid Receptor Antagonists
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1073-1083Informations de copyright
© 2022 Wiley Periodicals LLC.
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