Coordination of pancreatic islet rhythmic activity by delayed negative feedback.
bistability
insulin
microfluidics
oscillations
synchronization
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 12 2022
01 12 2022
Historique:
pubmed:
13
10
2022
medline:
7
12
2022
entrez:
12
10
2022
Statut:
ppublish
Résumé
Secretion of insulin from the pancreas is pulsatile, driven by intrinsic oscillations within individual islets of Langerhans. The secretions are coordinated among the many islets distributed throughout the pancreas producing a synchronized rhythm in vivo that is essential for maintaining normal glucose levels. One hypothesized mechanism for the coordination of islet activity is negative feedback, whereby sequestration of glucose in response to elevated insulin leads to a reduction in the blood glucose level that is sensed by the islet population. This global signal of glucose then coordinates the individual islets. In this study, we tested how this coordination mechanism is affected by time delays in the negative feedback, using a microfluidic system to monitor Ca
Identifiants
pubmed: 36223522
doi: 10.1152/ajpendo.00123.2022
pmc: PMC9722252
doi:
Substances chimiques
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
E492-E502Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK080714
Pays : United States
Organisme : HHS | NIH | Office of Extramural Research, National Institutes of Health (OER)
ID : R01 DK 080714
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