Illustration of Gut-Thyroid Axis in Alcohol Use Disorder: Interplay of Gut Dysfunction, Pro-Inflammatory Responses, and Thyroid Function.
Alcohol Drinking
Alcoholism
Cytokines
/ metabolism
Female
Humans
Interleukin-1beta
/ metabolism
Interleukin-6
/ metabolism
Interleukin-8
/ metabolism
Intestines
/ metabolism
Lipopolysaccharide Receptors
/ metabolism
Lipopolysaccharides
/ metabolism
Male
Plasminogen Activator Inhibitor 1
/ metabolism
Thyroid Gland
/ metabolism
Thyroid Hormones
/ metabolism
Thyrotropin
/ metabolism
Thyroxine
Triiodothyronine
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
alcohol use disorder
gut dysfunction
gut–thyroid axis
pro-inflammatory cytokines
thyroid-associated hormones
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
received:
09
09
2022
revised:
21
09
2022
accepted:
28
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
(1) Background: Heavy and chronic alcohol drinking leads to altered gut dysfunction, coupled with a pro-inflammatory state. Thyroid-associated hormones and proteins may be dysregulated by heavy and chronic alcohol intake; however, the mechanism for altered gut-derived changes in thyroid function has not been studied thus far. This study investigates the role of alcohol-induced gut dysfunction and pro-inflammatory cytokine profile in the thyroid function of patients with alcohol use disorder (AUD). (2) Methods: Male and female AUD patients (
Identifiants
pubmed: 36231061
pii: cells11193100
doi: 10.3390/cells11193100
pmc: PMC9563601
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-1beta
0
Interleukin-6
0
Interleukin-8
0
Lipopolysaccharide Receptors
0
Lipopolysaccharides
0
Plasminogen Activator Inhibitor 1
0
Thyroid Hormones
0
Tumor Necrosis Factor-alpha
0
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAAA NIH HHS
ID : K23 AA029198
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA170091
Pays : United States
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