Anti-Inflammatory Properties of the SGLT2 Inhibitor Empagliflozin in Activated Primary Microglia.
Animals
Anti-Inflammatory Agents
/ metabolism
Benzhydryl Compounds
Blood Glucose
/ metabolism
Glucosides
Hypoglycemic Agents
/ pharmacology
Inflammation
/ drug therapy
Inflammation Mediators
/ metabolism
Interleukin-10
/ metabolism
Interleukin-6
/ metabolism
Lipopolysaccharides
/ metabolism
Microglia
/ metabolism
NF-kappa B
/ metabolism
Rats
Sodium
/ metabolism
Sodium-Glucose Transporter 2
/ metabolism
Sodium-Glucose Transporter 2 Inhibitors
/ pharmacology
ERK1/2
IL6
NHE-1
SGLT1
SGLT2
TNF
empagliflozin
microglia
neurodegeneration
neuroinflammation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 10 2022
02 10 2022
Historique:
received:
17
06
2022
revised:
25
09
2022
accepted:
28
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, including empagliflozin, are routinely used as antidiabetic drugs. Recent studies indicate that beside its beneficial effects on blood glucose level, empagliflozin may also exert vascular anti-inflammatory and neuroprotective properties. In the brain, microglia are crucial mediators of inflammation, and neuroinflammation plays a key role in neurodegenerative disorders. Dampening microglia-mediated inflammation may slow down disease progression. In this context, we investigated the immunomodulatory effect of empagliflozin on activated primary microglia. As a validated experimental model, rat primary microglial cells were activated into a pro-inflammatory state by stimulation with LPS. The influence of empagliflozin on the expression of pro-inflammatory mediators (NO,
Identifiants
pubmed: 36231069
pii: cells11193107
doi: 10.3390/cells11193107
pmc: PMC9563452
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Benzhydryl Compounds
0
Blood Glucose
0
Glucosides
0
Hypoglycemic Agents
0
Inflammation Mediators
0
Interleukin-6
0
Lipopolysaccharides
0
NF-kappa B
0
Sodium-Glucose Transporter 2
0
Sodium-Glucose Transporter 2 Inhibitors
0
Interleukin-10
130068-27-8
Sodium
9NEZ333N27
empagliflozin
HDC1R2M35U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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