Dexmedetomidine Regulates the miR-146a-5p/NF-
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
08
2022
revised:
13
09
2022
accepted:
19
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Electroconvulsive therapy (ECT) is a nonpharmacological treatment for depressive episodes and other psychiatric disorders. It is used to control the condition by causing a transient loss of consciousness through electrical stimulation. Dexmedetomidine (DEX) is a novel and highly selective adrenergic agonist with sedative, sympathetic nerve activity inhibiting and stress-responsive effects. This study focused on the effect of DEX on cerebral protection after ECT treatment. 68 depression patients were enrolled and divided into control group and DEX group. The occurrence of delirium after ECT treatment in depression cases was recorded. In vivo, we constructed chronic mild and unpredictable stress (CUMS) rats to mimic depression model. Meanwhile, ECT treatment and DEX injection were administrated in CUMS rats. Learning and memory in rats were measured by Morris water maze test, open field test (OFT), and forced swimming test (FST). Finally, the expression of miR-146a-5p and NF-
Identifiants
pubmed: 36238484
doi: 10.1155/2022/8371492
pmc: PMC9553340
doi:
Substances chimiques
Adrenergic Agonists
0
Hypnotics and Sedatives
0
MicroRNAs
0
NF-kappa B
0
Dexmedetomidine
67VB76HONO
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
8371492Commentaires et corrections
Type : RetractionIn
Informations de copyright
Copyright © 2022 Xiaohui Zhou et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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