Sleep duration prior to an enterotoxigenic Escherichia coli challenge predicts diarrhea severity during infection.

Male Humans Female Enterotoxigenic Escherichia coli Antibodies, Bacterial Diarrhea / prevention & control Escherichia coli Infections / prevention & control Sleep
A C ETEC Sleep T cute diarrhea ontrolled human infection model raveler's diarrhea

Journal

Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759

Informations de publication

Date de publication:
12 2022
Historique:
received: 21 12 2021
revised: 09 09 2022
accepted: 11 09 2022
pubmed: 15 10 2022
medline: 15 11 2022
entrez: 14 10 2022
Statut: ppublish

Résumé

Acute diarrhea is the most frequent diagnosis among ill travelers. Sleep loss may weaken the body's defense against pathogens and increase susceptibility to infection. The relationship between sleep and infectious diarrhea has not been studied and was assessed utilizing data from a controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC). During a CHIM assessing the efficacy of an immunoprophylactic targeting ETEC against moderate-to-severe diarrhea (MSD) following challenge, we measured sleep via actigraphy over an 8-day inpatient period. We hypothesized better sleep pre-challenge would predict illness symptomatology following challenge. Among 57 participants (aged 34.4 ± 8.1 years, 64% male), there was no relationship between sleep metrics and incidence of MSD. However, longer total sleep time the night preceding ETEC challenge was associated with lower maximum 24 h diarrhea volume (B = -1.80, p = 0.01) and total diarrhea volume (B = -2.45, p = 0.01). This novel study showed that shorter sleep duration predicted diarrhea severity over the course of an ETEC infection. Future work should experimentally manipulate sleep to further clarify its impact on diarrhea-related outcomes for ETEC and other important enteric pathogens.

Sections du résumé

BACKGROUND
Acute diarrhea is the most frequent diagnosis among ill travelers. Sleep loss may weaken the body's defense against pathogens and increase susceptibility to infection. The relationship between sleep and infectious diarrhea has not been studied and was assessed utilizing data from a controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC).
METHODS
During a CHIM assessing the efficacy of an immunoprophylactic targeting ETEC against moderate-to-severe diarrhea (MSD) following challenge, we measured sleep via actigraphy over an 8-day inpatient period. We hypothesized better sleep pre-challenge would predict illness symptomatology following challenge.
RESULTS
Among 57 participants (aged 34.4 ± 8.1 years, 64% male), there was no relationship between sleep metrics and incidence of MSD. However, longer total sleep time the night preceding ETEC challenge was associated with lower maximum 24 h diarrhea volume (B = -1.80, p = 0.01) and total diarrhea volume (B = -2.45, p = 0.01).
CONCLUSIONS
This novel study showed that shorter sleep duration predicted diarrhea severity over the course of an ETEC infection. Future work should experimentally manipulate sleep to further clarify its impact on diarrhea-related outcomes for ETEC and other important enteric pathogens.

Identifiants

DOI: 10.1016/j.sleep.2022.09.008 PMID: 36240601
pubmed: 36240601
pii: S1389-9457(22)01136-4
doi: 10.1016/j.sleep.2022.09.008
pii:
doi:

Substances chimiques

Antibodies, Bacterial 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

404-409

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Janna Mantua (J)

Walter Reed Army Institute of Research, Behavioral Biology Branch, Silver Spring, MD, 20910, USA. Electronic address: janna.mantua@gmail.com.

Ramiro L Gutierrez (RL)

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.

Sandra D Isidean (SD)

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.

Ashley N Alcala (AN)

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.

Kayla J Testa (KJ)

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.

Kawsar R Talaat (KR)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Tracy Jill Doty (TJ)

Walter Reed Army Institute of Research, Behavioral Biology Branch, Silver Spring, MD, 20910, USA.

Chad K Porter (CK)

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sleep duration prior to an enterotoxigenic...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli entérotoxigène › Sleep duration prior to an enterotoxigenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antibactériens › Sleep duration prior to an enterotoxigenic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Diarrhée › Sleep duration prior to an enterotoxigenic...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Escherichia coli › Sleep duration prior to an enterotoxigenic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Sleep duration prior to an enterotoxigenic...