Structural basis for recognition of antihistamine drug by human histamine receptor.

Histamine / metabolism Histamine Antagonists / pharmacology Humans Ligands Molecular Docking Simulation Receptors, G-Protein-Coupled / metabolism Receptors, Histamine / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
15 10 2022
Historique:
received: 23 12 2021
accepted: 05 10 2022
entrez: 15 10 2022
pubmed: 16 10 2022
medline: 19 10 2022
Statut: epublish

Résumé

The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and play important roles in the regulation of histamine and other neurotransmitters in the central nervous system, as potential targets for the treatment of neurologic and psychiatric disorders. Here we report the crystal structure of human histamine receptor H

Identifiants

DOI: 10.1038/s41467-022-33880-y PMID: 36243875 PMC: PMC9569329
pubmed: 36243875
doi: 10.1038/s41467-022-33880-y
pii: 10.1038/s41467-022-33880-y
pmc: PMC9569329
doi:

Substances chimiques

Histamine Antagonists 0
Ligands 0
Receptors, G-Protein-Coupled 0
Receptors, Histamine 0
Histamine 820484N8I3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6105

Informations de copyright

© 2022. The Author(s).

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Auteurs

Xueqian Peng (X)

Hangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
ORCID: 0000-0003-1701-2924

Linlin Yang (L)

Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, 450052, Zhengzhou, Henan, China.

Zixuan Liu (Z)

Hangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
ORCID: 0000-0001-5690-4808

Siyi Lou (S)

Hangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
ORCID: 0000-0002-3481-4905

Shiliu Mei (S)

Hangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.

Meiling Li (M)

Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, 450052, Zhengzhou, Henan, China.

Zhong Chen (Z)

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 310053, Hangzhou, Zhejiang, China.
ORCID: 0000-0003-4755-9357

Haitao Zhang (H)

Hangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China. haitaozhang@zju.edu.cn.
The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China. haitaozhang@zju.edu.cn.
ORCID: 0000-0003-4879-2951

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Histamine › Structural basis for recognition of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents histaminiques › Antihistaminiques › Structural basis for recognition of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural basis for recognition of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Structural basis for recognition of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Structural basis for recognition of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Structural basis for recognition of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs histaminergiques › Structural basis for recognition of...