Alkaloids with cholinesterase inhibitory activities from the bulbs of Crinum × amabile Donn ex Ker Gawl.
Acetylcholinesterase
Alkaloids
Amaryllidaceae
Butyrylcholinesterase
Crinum × amabile Donn ex Ker Gawl.
Molecular docking
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
11
05
2022
revised:
01
09
2022
accepted:
10
10
2022
pubmed:
17
10
2022
medline:
15
12
2022
entrez:
16
10
2022
Statut:
ppublish
Résumé
Seven previously undescribed alkaloids, crinamabilines A-G, two non-alkaloidal compounds, crinamabidiene and 6-phenylpiperonyl alcohol, two first naturally occurring alkaloids, 3-epibuphanisine and (+)-1β,2β-epoxy-epicrinine, together with nineteen known alkaloids, were isolated from the bulbs of Crinum × amabile Donn ex Ker Gawl. Their structures and absolute configurations were elucidated by NMR, MS and ECD spectroscopic techniques. Ungeremine displayed the most potent inhibitory activity against acetylcholinesterase (IC
Identifiants
pubmed: 36244402
pii: S0031-9422(22)00389-2
doi: 10.1016/j.phytochem.2022.113473
pii:
doi:
Substances chimiques
Butyrylcholinesterase
EC 3.1.1.8
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113473Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.