Cytotoxicity of Hybrid Noble Metal-Polymer Composites.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
07
2022
revised:
08
09
2022
accepted:
15
09
2022
entrez:
21
10
2022
pubmed:
22
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca
Identifiants
pubmed: 36267838
doi: 10.1155/2022/1487024
pmc: PMC9578826
doi:
Substances chimiques
Silver
3M4G523W1G
Polymers
0
Reactive Oxygen Species
0
Dextrans
0
Gold
7440-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1487024Informations de copyright
Copyright © 2022 Anton Tkachenko et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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