In vitro synergistic action of TAT-RasGAP

Anti-Bacterial Agents / pharmacology Microbial Sensitivity Tests ras GTPase-Activating Proteins / pharmacology Anti-Infective Agents / pharmacology Bacteria Escherichia coli
Acinetobacter baumannii Antibiotic resistance Antimicrobial peptides Biofilm Escherichia coli Pseudomonas aeruginosa

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
12 2022
Historique:
received: 18 08 2022
revised: 05 10 2022
accepted: 11 10 2022
pubmed: 22 10 2022
medline: 21 12 2022
entrez: 21 10 2022
Statut: ppublish

Résumé

Multidrug-resistant (MDR) bacteria are a continuously increasing threat for medicine, causing infections recalcitrant to antibiotics. Antimicrobial peptides (AMPs) were identified as alternatives to antibiotics, being naturally occurring short peptides and part of the innate immune system of a vast majority of organisms. However, the clinical application of AMPs is limited by suboptimal pharmacokinetic properties and relatively high toxicity. Combinatorial treatments using AMPs and classical antibiotics may decrease the concentrations of AMPs required for bacterial eradication, thus lowering the side effects of these peptides. Here, we investigate the in vitro efficiency of combinations of the recently described antimicrobial peptide TAT-RasGAP We identified synergistic combinations towards all three bacteria and demonstrated that these combinations had an increased bactericidal effect compared to individual drugs. Moreover, combinations were also effective against clinical isolates of A. baumannii. Finally, combination of TAT-RasGAP Taken together, our results indicate that combinations of TAT-RasGAP

Identifiants

DOI: 10.1016/j.jgar.2022.10.003 PMID: 36270448
pubmed: 36270448
pii: S2213-7165(22)00236-3
doi: 10.1016/j.jgar.2022.10.003
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
TAT-RasGAP(317-326) 0
ras GTPase-Activating Proteins 0
Anti-Infective Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

295-303

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing interests.

Auteurs

Grazia Vizzarro (G)

Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.

Nicolas Jacquier (N)

Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland. Electronic address: nicolas.jacquier@chuv.ch.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › In vitro synergistic action of TAT-RasGAP
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › In vitro synergistic action of TAT-RasGAP
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Protéines d'activation de la ras GTPase › In vitro synergistic action of TAT-RasGAP
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › In vitro synergistic action of TAT-RasGAP
questionsmedicales.fr › Bactéries › In vitro synergistic action of TAT-RasGAP
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › In vitro synergistic action of TAT-RasGAP