Predicting the configuration and energy of DNA in a nucleosome by coarse-grain modelling.

Nucleosome-binding propensities of DNA are crucial for understanding gene expression and regulation. Therefore, it is important to understand how specific DNA sequences self-organise and optimise the process of wrapping into the nucleosomes. To this end, we develop a procedure to predict the configuration needed for nucleosome forming. We start with examining a set of chosen experimental structures of nucleosomes to find regularities. This classification allows us to define structural constraints for DNA wound around histones. We then use the