Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
09
04
2021
accepted:
06
09
2022
pubmed:
26
10
2022
medline:
5
11
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
Decisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that basolateral amygdala (BLA) neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic (PL) region of the prefrontal cortex mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives for decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.
Identifiants
pubmed: 36280797
doi: 10.1038/s41593-022-01179-2
pii: 10.1038/s41593-022-01179-2
pmc: PMC7613781
mid: EMS153929
doi:
Banques de données
Dryad
['10.5061/dryad.bnzs7h4dv']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1505-1518Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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