Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa.
African
BAT25
BAT26
Colorectal cancer
Low level microsatellite instability
Microsatellite stable
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
24 Oct 2022
24 Oct 2022
Historique:
received:
25
08
2021
accepted:
14
10
2022
entrez:
25
10
2022
pubmed:
26
10
2022
medline:
27
10
2022
Statut:
epublish
Résumé
A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associated with different clinicopathological and molecular features. This study aimed to ascertain key histopathological features in microsatellite stable (MSS) and low-frequency MSI (MSI-L) patients, to provide insight into the mechanism of the disease. A retrospective cohort (2011-2015) of MSS/MSI-L CRC patient samples diagnosed at Charlotte Maxeke Johannesburg Academic Hospital was analyzed. Samples were categorized by site [right colon cancer (RCC) versus left (LCC)], ethnicity [IA versus other ethnic groups (OEG)] and MSI status (MSI-L vs MSS). T-test, Fischer's exact and Chi-square tests were conducted. IA patients with LCC demonstrated an increased prevalence in males, sigmoid colon, signet-ring-cell morphology, MSI-L with BAT25/26 marker instability and advanced disease association. This study revealed distinct histopathological features for LCC, and suggests BAT25 and BAT26 as negative prognostic markers in African CRC patients. Larger confirmatory studies are recommended.
Identifiants
pubmed: 36280820
doi: 10.1186/s12885-022-10185-3
pii: 10.1186/s12885-022-10185-3
pmc: PMC9590207
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1089Informations de copyright
© 2022. The Author(s).
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