Lack of Retinoblastoma Protein Shifts Tumor Metabolism from Glycolysis to OXPHOS and Allows the Use of Alternate Fuels.
Child
Humans
Retinoblastoma Protein
/ genetics
NAD
/ metabolism
Hexokinase
/ metabolism
Glutamine
/ metabolism
Retinoblastoma
Glycolysis
/ genetics
Glucose
/ metabolism
Fatty Acids
/ metabolism
Retinal Neoplasms
Adenosine Triphosphate
/ metabolism
Transcription Factors
/ metabolism
Carnitine
Tricarboxylic Acids
Pyruvates
OCR
OXPHOS
energetics
glycolysis
metabolism
retinoblastoma
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 10 2022
11 10 2022
Historique:
received:
31
07
2022
revised:
08
09
2022
accepted:
30
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Mutations in the
Identifiants
pubmed: 36291051
pii: cells11203182
doi: 10.3390/cells11203182
pmc: PMC9600484
pii:
doi:
Substances chimiques
Retinoblastoma Protein
0
NAD
0U46U6E8UK
Hexokinase
EC 2.7.1.1
Glutamine
0RH81L854J
Glucose
IY9XDZ35W2
Fatty Acids
0
Adenosine Triphosphate
8L70Q75FXE
Transcription Factors
0
Carnitine
S7UI8SM58A
Tricarboxylic Acids
0
Pyruvates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Res. 1982 Oct;42(10):4228-32
pubmed: 7105015
Oncotarget. 2015 Oct 13;6(31):30453-71
pubmed: 26421711
Oncogene. 2016 Jul 14;35(28):3619-25
pubmed: 26592449
Tumour Biol. 2016 Mar;37(3):3887-95
pubmed: 26476538
Br J Cancer. 2015 Oct 20;113(8):1216-24
pubmed: 26348444
Cancer Discov. 2021 Sep;11(9):2334-2353
pubmed: 33879449
Ocul Surf. 2016 Apr;14(2):168-88
pubmed: 26882981
Oncogene. 2010 Jan 21;29(3):313-24
pubmed: 19881548
Trends Cancer. 2017 Nov;3(11):768-779
pubmed: 29120753
Oncogene. 2014 Jan 30;33(5):556-66
pubmed: 23353822
Cell Syst. 2018 Jul 25;7(1):49-62.e8
pubmed: 29960885
Nature. 2014 Oct 16;514(7522):385-8
pubmed: 25252974
Cell Rep. 2018 May 29;23(9):2629-2642
pubmed: 29847794
Nature. 2011 Nov 20;481(7381):380-4
pubmed: 22101433
J Clin Invest. 2016 Oct 3;126(10):3739-3757
pubmed: 27571409
Nature. 1986 Oct 16-22;323(6089):643-6
pubmed: 2877398
Nat Protoc. 2018 Dec;13(12):2991-3017
pubmed: 30455477
Onco Targets Ther. 2020 Nov 11;13:11583-11594
pubmed: 33204111
J Neurosci Res. 2015 Jul;93(7):1079-92
pubmed: 25801286
Arch Ophthalmol. 2012 Jun;130(6):724-9
pubmed: 22801832
Mol Cell Proteomics. 2011 Mar;10(3):M110.002469
pubmed: 21173383
Front Oncol. 2020 Mar 06;10:317
pubmed: 32211335
FEBS Lett. 2019 Jan;593(1):23-41
pubmed: 30417337
Cell. 2016 Jul 28;166(3):555-566
pubmed: 27471965
Curr Opin Ophthalmol. 2010 May;21(3):203-12
pubmed: 20224400
Cell Res. 2018 Mar;28(3):265-280
pubmed: 29219147
Br J Cancer. 2020 Jan;122(1):4-22
pubmed: 31819192
Cells. 2022 May 18;11(10):
pubmed: 35626705
Oncogene. 2006 Aug 7;25(34):4683-96
pubmed: 16892082
Oncogenesis. 2017 Jun 26;6(6):e350
pubmed: 28650445
Front Oncol. 2020 Mar 31;10:428
pubmed: 32296646
Cells. 2020 Dec 04;9(12):
pubmed: 33291682
Cancers (Basel). 2021 Apr 01;13(7):
pubmed: 33915900
Nat Biotechnol. 2013 Jun;31(6):522-9
pubmed: 23604282
Cancer. 1994 Feb 1;73(3):692-8
pubmed: 8299091