Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study.
Animals
Rats
Coumaric Acids
/ therapeutic use
Cholinesterase Inhibitors
/ chemistry
Acetylcholinesterase
/ metabolism
Antioxidants
/ chemistry
Carrageenan
/ therapeutic use
GABA Uptake Inhibitors
/ therapeutic use
Reducing Agents
Alzheimer Disease
/ drug therapy
Nipecotic Acids
/ therapeutic use
Piperidines
/ therapeutic use
Anti-Inflammatory Agents
/ pharmacology
Alzheimer’s Disease
acetylcholinesterase inhibitors
inflammation
multi-targeting compounds
nipecotic acid
oxidative stress
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 Oct 2022
17 Oct 2022
Historique:
received:
14
09
2022
revised:
13
10
2022
accepted:
14
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Alzheimer's Disease (AD) is a common neurodegenerative disorder characterized by memory loss and cognitive impairment. Its pathology has not been fully clarified and therefore highly effective treatments have not been obtained yet. Almost all the current treatment options aim to alleviate only the symptoms and not to eliminate the disease itself. Acetylcholinesterase inhibitors are the main therapeutic agents against AD, whereas oxidative stress and inflammation have been found to be of great significance for the development and progression of neurodegeneration. In this work, ethyl nipecotate (ethyl-piperidine-3-carboxylate), a heterocyclic carboxylic acid derivative, which acts as a GABA reuptake inhibitor and has been used in research for diseases involving GABAergic neurotransmission dysfunction, was amidated with various carboxylic acids bearing antioxidant and/or anti-inflammatory properties (e.g., ferulic acid, sinapic acid, butylated hydroxycinnamic acid). Most of our compounds have significant antioxidant potency as lipid peroxidation inhibitors (IC
Identifiants
pubmed: 36296574
pii: molecules27206984
doi: 10.3390/molecules27206984
pmc: PMC9609801
pii:
doi:
Substances chimiques
Coumaric Acids
0
Cholinesterase Inhibitors
0
Acetylcholinesterase
EC 3.1.1.7
Antioxidants
0
Carrageenan
9000-07-1
GABA Uptake Inhibitors
0
Reducing Agents
0
Nipecotic Acids
0
Piperidines
0
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Neurosci Bull. 2014 Apr;30(2):271-81
pubmed: 24664866
J Neuroimmunol. 2013 Jan 15;254(1-2):1-9
pubmed: 23021418
Med Chem. 2017;13(3):214-225
pubmed: 27823562
J Pathol. 1971 May;104(1):15-29
pubmed: 4398139
Front Neurosci. 2018 Mar 22;12:163
pubmed: 29623026
Rev Neurosci. 2020 May 26;31(4):391-413
pubmed: 32017704
J Nutr Biochem. 2002 May;13(5):273-281
pubmed: 12015157
Neuropharmacology. 2021 Jun 1;190:108352
pubmed: 33035532
Pharmacol Biochem Behav. 2012 Dec;103(2):260-6
pubmed: 22971592
Antioxidants (Basel). 2020 Dec 24;10(1):
pubmed: 33374280
FASEB J. 2008 Apr;22(4):1169-78
pubmed: 17998412
Molecules. 2021 Nov 26;26(23):
pubmed: 34885751
Front Aging Neurosci. 2019 Aug 30;11:233
pubmed: 31543810
Heart Rhythm. 2010 Apr;7(4):433-7
pubmed: 20122875
Med Chem. 2021;17(10):1086-1103
pubmed: 33050864
Molecules. 2019 Sep 09;24(18):
pubmed: 31505754
Front Cell Neurosci. 2015 Dec 02;9:464
pubmed: 26696824
Ageing Res Rev. 2013 Jan;12(1):39-49
pubmed: 22771380
Redox Biol. 2018 Apr;14:450-464
pubmed: 29080524
Brain. 2018 Jul 1;141(7):1917-1933
pubmed: 29850777
Eur J Med Chem. 2018 Jun 10;153:65-72
pubmed: 29133059
N Engl J Med. 2010 Jan 28;362(4):329-44
pubmed: 20107219
Mini Rev Med Chem. 2021;21(1):10-22
pubmed: 32767937
J Neurochem. 2017 Aug;142 Suppl 2:111-121
pubmed: 28791706
Molecules. 2022 Apr 11;27(8):
pubmed: 35458662
Neurotherapeutics. 2019 Oct;16(4):1255-1268
pubmed: 31392591
Eur J Pharm Sci. 2018 Jun 5;121:356-381
pubmed: 29883727
ACS Chem Neurosci. 2019 Feb 20;10(2):1008-1024
pubmed: 30537804
Mol Neurobiol. 2016 Jan;53(1):648-661
pubmed: 25511446
ACS Chem Neurosci. 2018 May 16;9(5):988-1000
pubmed: 29384651
Neurochem Res. 2016 Feb;41(1-2):243-57
pubmed: 26677076
Bioorg Med Chem. 2006 Aug 15;14(16):5616-24
pubmed: 16690318
Molecules. 2021 Jul 02;26(13):
pubmed: 34279399
Bioorg Med Chem Lett. 2017 Nov 1;27(21):4800-4804
pubmed: 29017787
Pharmacol Rep. 2015 Apr;67(2):195-203
pubmed: 25712639
Brain Behav Immun. 2021 Nov;98:337-348
pubmed: 34500034
Molecules. 2022 Mar 24;27(7):
pubmed: 35408503
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10837-42
pubmed: 12119423