Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS.
acute respiratory distress syndrome
cell-free DNA
glycocalyx
sepsis
syndecan-1
vitamin C
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
02
08
2022
revised:
15
09
2022
accepted:
30
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
(1) Background: The disease-modifying mechanisms of high-dose intravenous vitamin C (HDIVC) in sepsis induced acute respiratory distress syndrome (ARDS) is unclear. (2) Methods: We performed a post hoc study of plasma biomarkers from subjects enrolled in the randomized placebo-controlled trial CITRIS-ALI. We explored the effects of HDIVC on cell-free DNA (cfDNA) and syndecan-1, surrogates for neutrophil extracellular trap (NET) formation and degradation of the endothelial glycocalyx, respectively. (3) Results: In 167 study subjects, baseline cfDNA levels in HDIVC (84 subjects) and placebo (83 subjects) were 2.18 ng/µL (SD 4.20 ng/µL) and 2.65 ng/µL (SD 3.87 ng/µL), respectively,
Identifiants
pubmed: 36297099
pii: nu14204415
doi: 10.3390/nu14204415
pmc: PMC9610384
pii:
doi:
Substances chimiques
Syndecan-1
0
Ascorbic Acid
PQ6CK8PD0R
Vitamins
0
Biomarkers
0
Cell-Free Nucleic Acids
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Heart Lung and Blood Institute
ID : UM1HL116885
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