Metabolic features of innate lymphoid cells.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
07 11 2022
07 11 2022
Historique:
received:
05
07
2022
revised:
31
08
2022
accepted:
04
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
1
11
2022
Statut:
ppublish
Résumé
Innate and adaptive immune cells are found in distinct tissue niches where they orchestrate immune responses. This requires intrinsic and temporal metabolic adaptability to coordinately activate the immune response cascade. Dysregulation of this program is a key feature of immunosuppression. Direct or indirect metabolic immune cell reprogramming may offer new approaches to modulate immune cells behavior for therapy to overcome dysregulation. In this review, we explored how metabolism regulates lymphocytes beyond the classical T cell subsets. We focus on the innate lymphoid cell (ILC) family, highlighting the distinct metabolic characteristics of these cells, the impact of environmental factors, and the receptors that could alter immune cell functions through manipulation of metabolic pathways to potentially prevent or treat various diseases.
Identifiants
pubmed: 36301303
pii: 213615
doi: 10.1084/jem.20221140
pmc: PMC9617479
pii:
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Health and Medical Research Council
ID : 1165443
Organisme : University of Queensland
Organisme : Cancer Council NSW
ID : RG 21-05
Organisme : Cancer Australia
ID : 1163990
Organisme : Cure Cancer
Organisme : Australian Government
Informations de copyright
© 2022 Crown copyright. The government of Australia, Canada, or the UK ("the Crown") owns the copyright interests of authors who are government employees. The Crown Copyright is not transferable.
Références
Nature. 2020 Mar;579(7797):130-135
pubmed: 32076273
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):
pubmed: 34183415
Immunity. 2018 Feb 20;48(2):258-270.e5
pubmed: 29452935
Nat Rev Cancer. 2003 Oct;3(10):721-32
pubmed: 13130303
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Nat Immunol. 2015 Feb;16(2):161-9
pubmed: 25531830
J Transl Med. 2021 Dec 7;19(1):499
pubmed: 34876185
Front Immunol. 2019 Sep 27;10:2318
pubmed: 31611881
J Immunol. 2016 Mar 15;196(6):2552-60
pubmed: 26873994
Nat Immunol. 2016 Jun;17(6):646-55
pubmed: 27111142
Nat Rev Immunol. 2020 Jan;20(1):55-70
pubmed: 31406325
Nature. 2010 Apr 29;464(7293):1367-70
pubmed: 20200518
Immunity. 2010 Nov 24;33(5):736-51
pubmed: 21093318
Immunity. 2015 Jul 21;43(1):146-60
pubmed: 26187413
J Crohns Colitis. 2022 Aug 30;16(8):1293-1305
pubmed: 35134872
Cell. 2016 Oct 20;167(3):829-842.e13
pubmed: 27745970
Nat Commun. 2021 May 5;12(1):2538
pubmed: 33953160
Blood. 2011 Feb 3;117(5):1565-73
pubmed: 21127177
Nat Rev Immunol. 2019 May;19(5):282-290
pubmed: 30808985
Nat Immunol. 2018 Dec;19(12):1330-1340
pubmed: 30420624
J Clin Invest. 2015 Jan;125(1):194-207
pubmed: 25437876
Biochem Soc Trans. 2006 Apr;34(Pt 2):223-7
pubmed: 16545081
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
J Immunol. 2016 Mar 1;196(5):2283-92
pubmed: 26826241
Blood. 2020 Dec 24;136(26):3004-3017
pubmed: 32818230
Nat Commun. 2015 Mar 26;6:6692
pubmed: 25809635
J Exp Med. 2016 Jul 25;213(8):1409-18
pubmed: 27432938
J Cell Biol. 1992 Jun;117(5):959-73
pubmed: 1374417
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Adv Drug Deliv Rev. 2021 Sep;176:113860
pubmed: 34237404
Nature. 2009 Jul 2;460(7251):108-12
pubmed: 19543266
J Immunol. 2003 May 15;170(10):5018-26
pubmed: 12734346
Nature. 2002 Nov 7;420(6911):78-84
pubmed: 12422218
Nat Immunol. 2021 Nov;22(11):1367-1374
pubmed: 34686862
Metabolism. 2021 Jan;114:154338
pubmed: 32791172
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1915-9
pubmed: 19181844
Nat Immunol. 2021 Jul;22(7):851-864
pubmed: 34099918
Blood. 2012 Aug 16;120(7):1422-31
pubmed: 22786879
Science. 2018 Nov 2;362(6414):589-595
pubmed: 30385579
J Clin Invest. 2021 Apr 1;131(7):
pubmed: 33792560
J Clin Invest. 2022 Jan 4;132(1):
pubmed: 34981777
Curr Opin Immunol. 2017 Jun;46:14-22
pubmed: 28412583
Annu Rev Biomed Eng. 2017 Jun 21;19:163-194
pubmed: 28301735
Eur J Immunol. 2013 Oct;43(10):2756-64
pubmed: 23913266
Immunity. 2013 Apr 18;38(4):633-43
pubmed: 23601682
PLoS One. 2011;6(5):e20107
pubmed: 21611151
Sci Rep. 2021 Mar 19;11(1):6472
pubmed: 33742092
Cell Metab. 2021 Dec 7;33(12):2415-2427.e6
pubmed: 34879240
Cell Metab. 2019 Jul 2;30(1):143-156.e5
pubmed: 31031094
Nat Immunol. 2014 Aug;15(8):749-757
pubmed: 24973821
Cells. 2020 Dec 24;10(1):
pubmed: 33374128
Nat Immunol. 2013 May;14(5):489-99
pubmed: 23563690
iScience. 2020 Jun 26;23(6):101171
pubmed: 32480123
J Immunol. 2013 Aug 15;191(4):1818-26
pubmed: 23851685
Cell Death Dis. 2019 Apr 8;10(4):315
pubmed: 30962426
Nature. 2021 Sep;597(7877):544-548
pubmed: 34526724
Nat Immunol. 2021 Feb;22(2):166-178
pubmed: 33432227
Front Immunol. 2020 Aug 21;11:1906
pubmed: 32973789
J Exp Med. 2011 Jul 4;208(7):1367-76
pubmed: 21708926
Mucosal Immunol. 2021 Jul;14(4):828-841
pubmed: 33446906
Cell Metab. 2006 Jul;4(1):13-24
pubmed: 16814729
Immunity. 2016 Jul 19;45(1):198-208
pubmed: 27421705
Nat Immunol. 2009 Jan;10(1):75-82
pubmed: 19029904
Nat Immunol. 2016 Jun;17(6):656-65
pubmed: 27043409
Nat Immunol. 2019 Jul;20(7):793-801
pubmed: 31213715
Immunity. 2012 Oct 19;37(4):634-48
pubmed: 23063333
JCI Insight. 2018 Feb 8;3(3):
pubmed: 29415897
Nature. 2018 Oct;562(7727):423-428
pubmed: 30305738
Front Immunol. 2019 Jun 19;10:1414
pubmed: 31275330
Blood. 2007 Dec 15;110(13):4588-98
pubmed: 17827390
Science. 2022 Feb 25;375(6583):859-863
pubmed: 35201883
Clin Transl Immunology. 2020 Dec 22;9(12):e1228
pubmed: 33363733
Cell. 2015 Sep 10;162(6):1217-28
pubmed: 26321681
Immunity. 2009 Jun 19;30(6):832-44
pubmed: 19538929
Mol Cell. 2010 Jul 30;39(2):171-83
pubmed: 20670887
Immunity. 2007 Oct;27(4):670-84
pubmed: 17950003
Front Immunol. 2020 Aug 28;11:1989
pubmed: 32983138
J Immunol. 2015 Feb 15;194(4):1954-62
pubmed: 25595780
Front Immunol. 2014 Apr 23;5:187
pubmed: 24795729
Immunity. 2020 Jun 16;52(6):1075-1087.e8
pubmed: 32445619
Curr Opin Immunol. 2019 Feb;56:10-16
pubmed: 30240964
J Mol Biol. 2017 Nov 24;429(23):3577-3586
pubmed: 28867535
Mucosal Immunol. 2021 Jan;14(1):164-176
pubmed: 32355319
Nat Rev Immunol. 2020 Jun;20(6):375-388
pubmed: 32132681
Annu Rev Immunol. 2014;32:609-34
pubmed: 24655299
Science. 2014 Sep 26;345(6204):1250684
pubmed: 25258083
Cell Metab. 2006 Mar;3(3):187-97
pubmed: 16517406
Cell. 2017 May 4;169(4):570-586
pubmed: 28475890
Nat Metab. 2022 Jul;4(7):867-882
pubmed: 35788761
Blood Adv. 2021 Jan 12;5(1):26-38
pubmed: 33570622
Nat Immunol. 2012 Jan 22;13(3):229-36
pubmed: 22267218
Science. 2013 Oct 11;342(6155):1242454
pubmed: 24115444
Cancer Res. 2012 Aug 1;72(15):3709-14
pubmed: 22787121
J Exp Med. 2021 Dec 6;218(12):
pubmed: 34813654
Cell Metab. 2021 Jun 1;33(6):1205-1220.e5
pubmed: 33852875
Nat Immunol. 2013 Nov;14(11):1173-82
pubmed: 24076634
J Immunol. 2007 Feb 15;178(4):2163-70
pubmed: 17277121
J Clin Invest. 2002 May;109(9):1125-31
pubmed: 11994399
Nat Rev Endocrinol. 2016 Jan;12(1):15-28
pubmed: 26553134
J Exp Med. 2009 Jan 16;206(1):35-41
pubmed: 19114665
Cell. 2016 Aug 25;166(5):1117-1131.e14
pubmed: 27565342
J Immunol. 2011 Mar 15;186(6):3299-303
pubmed: 21317389
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Cell. 2013 Jun 6;153(6):1239-51
pubmed: 23746840
Cell Rep. 2022 Apr 19;39(3):110715
pubmed: 35443177
Nat Commun. 2018 Jun 14;9(1):2341
pubmed: 29904050
Nat Commun. 2020 Aug 10;11(1):3998
pubmed: 32778730
Nat Rev Immunol. 2021 Dec;21(12):785-797
pubmed: 33927375
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Annu Rev Immunol. 2018 Apr 26;36:461-488
pubmed: 29677474
Nat Immunol. 2016 Apr;17(4):406-13
pubmed: 26950237
Cell Metab. 2014 Jul 1;20(1):61-72
pubmed: 24930970
Immunity. 2009 May;30(5):646-55
pubmed: 19464987
Cancer Immunol Res. 2018 Nov;6(11):1375-1387
pubmed: 30143538
J Immunol. 2014 Apr 15;192(8):3626-36
pubmed: 24616478
Nature. 2016 Sep 22;537(7621):539-543
pubmed: 27626381
Cell. 2017 Apr 6;169(2):361-371
pubmed: 28388417
Nat Immunol. 2016 Jun 21;17(7):790-4
pubmed: 27328009
Immunity. 2013 Aug 22;39(2):372-85
pubmed: 23973224
J Exp Med. 2022 Feb 7;219(2):
pubmed: 35024767
Front Immunol. 2019 Dec 13;10:2915
pubmed: 31921174
Nature. 2016 Mar 31;531(7596):651-5
pubmed: 26982734
Blood. 2002 Nov 15;100(10):3633-8
pubmed: 12393617
Front Immunol. 2021 Oct 25;12:757967
pubmed: 34759931
World J Gastroenterol. 2018 Aug 21;24(31):3500-3512
pubmed: 30131656
J Exp Med. 2009 Jan 16;206(1):25-34
pubmed: 19103877
Sci Immunol. 2019 Jan 18;4(31):
pubmed: 30658968
Cell. 2021 Sep 16;184(19):5015-5030.e16
pubmed: 34407392
J Immunol. 2018 Jun 15;200(12):3934-3941
pubmed: 29720425
Nature. 2021 Apr;592(7852):128-132
pubmed: 33536623
Nat Immunol. 2017 Sep;18(9):995-1003
pubmed: 28759002
Nat Immunol. 2017 Nov;18(11):1197-1206
pubmed: 28920951
Cell. 2016 Aug 25;166(5):1231-1246.e13
pubmed: 27545347
Immunity. 2013 Apr 18;38(4):769-81
pubmed: 23453631
J Exp Med. 2019 Oct 7;216(10):2231-2241
pubmed: 31296736
Biology (Basel). 2013 Jan 29;2(1):284-303
pubmed: 24832661
Sci Signal. 2016 Feb 16;9(415):ra19
pubmed: 26884601
Cell Res. 2020 Apr;30(4):300-314
pubmed: 32132672
Mol Immunol. 2019 Nov;115:3-11
pubmed: 29179986
Annu Rev Immunol. 2013;31:259-83
pubmed: 23298210
Immunity. 2012 Jan 27;36(1):55-67
pubmed: 22261438
J Immunol. 2017 Sep 15;199(6):1967-1972
pubmed: 28784848
Semin Immunol. 2019 Feb;41:101271
pubmed: 30902413
Nat Immunol. 2017 Sep;18(9):1004-1015
pubmed: 28759001
Immunity. 2020 May 19;52(5):885
pubmed: 32433951
Immunity. 2008 Dec 19;29(6):958-70
pubmed: 19084435
Blood. 2009 Apr 30;113(18):4240-9
pubmed: 19171879
Immunity. 1997 Oct;7(4):493-504
pubmed: 9354470
Adv Cancer Res. 2019;143:195-253
pubmed: 31202359
Nat Immunol. 2016 Jun;17(6):636-45
pubmed: 27111145
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Nat Immunol. 2009 Jan;10(1):66-74
pubmed: 19029905
J Immunol. 2014 Nov 1;193(9):4477-84
pubmed: 25261477
Immunity. 2015 Sep 15;43(3):421-34
pubmed: 26377896