Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.

Animals Mice CD8-Positive T-Lymphocytes / immunology Lymphocyte Activation Mitochondria / metabolism Mitochondrial Trifunctional Protein, alpha Subunit / metabolism Mitochondrial Trifunctional Protein, beta Subunit / metabolism Spermidine / pharmacology Neoplasms / immunology

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
28 10 2022
Historique:
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 1 11 2022
Statut: ppublish

Résumé

Spermidine (SPD) delays age-related pathologies in various organisms. SPD supplementation overcame the impaired immunotherapy against tumors in aged mice by increasing mitochondrial function and activating CD8

Identifiants

DOI: 10.1126/science.abj3510 PMID: 36302005
pubmed: 36302005
doi: 10.1126/science.abj3510
doi:

Substances chimiques

Mitochondrial Trifunctional Protein, alpha Subunit EC 1.1.1.211
Mitochondrial Trifunctional Protein, beta Subunit EC 2.3.1.16
Spermidine U87FK77H25

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabj3510

Commentaires et corrections

Type : CommentIn

Auteurs

Muna Al-Habsi (M)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
National Genetic Center, Ministry of Health, Muscat, Oman.
Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-2860-256X

Kenji Chamoto (K)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0001-8625-3612

Ken Matsumoto (K)

Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.
ORCID: 0000-0002-3899-3672

Norimichi Nomura (N)

Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-6330-2239

Baihao Zhang (B)

Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
ORCID: 0000-0002-3456-2509

Yuki Sugiura (Y)

Department of Biochemistry, Keio University, Tokyo, Japan.
ORCID: 0000-0002-6983-8958

Kazuhiro Sonomura (K)

Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Life Science Research Center, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.

Aprilia Maharani (A)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-2223-3222

Yuka Nakajima (Y)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-7357-2910

Yibo Wu (Y)

YCI Laboratory for Next-Generation Proteomics, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Chemical Biology Mass Spectrometry Platform, Faculty of Science, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-8256-3901

Yayoi Nomura (Y)

Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Rosemary Menzies (R)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-1894-5657

Masaki Tajima (M)

Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-3407-0229

Koji Kitaoka (K)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-1249-6384

Yasuharu Haku (Y)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-5708-9275

Sara Delghandi (S)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-8838-0145

Keiko Yurimoto (K)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-5854-8533

Fumihiko Matsuda (F)

Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-4557-4553

So Iwata (S)

Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-1735-2937

Toshihiko Ogura (T)

Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.
ORCID: 0000-0002-3001-1443

Sidonia Fagarasan (S)

Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
ORCID: 0000-0003-2086-6402

Tasuku Honjo (T)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-2300-3928

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Spermidine activates mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Spermidine activates mitochondrial...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Spermidine activates mitochondrial...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Spermidine activates mitochondrial...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Spermidine activates mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéine trifonctionnelle mitochondriale › Sous-unité alpha de la protéine trifonctionnelle mitochondriale › Spermidine activates mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéine trifonctionnelle mitochondriale › Sous-unité bêta de la protéine trifonctionnelle mitochondriale › Spermidine activates mitochondrial...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Spermidine › Spermidine activates mitochondrial...
questionsmedicales.fr › Tumeurs › Spermidine activates mitochondrial...