Lasmiditan promotes recovery from acute kidney injury through induction of mitochondrial biogenesis.
acute kidney injury
fibrosis
microvasculature injury
mitochondrial biogenesis
mitochondrial dysfunction
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
pmc-release:
01
01
2024
pubmed:
4
11
2022
medline:
20
12
2022
entrez:
3
11
2022
Statut:
ppublish
Résumé
Acute kidney injury (AKI) involves rapid loss of renal function and occurs in 8-16% of hospitalized patients. AKI can be induced by drugs, sepsis, and ischemia-reperfusion (I/R). Hallmarks of AKI include mitochondrial and microvasculature dysfunction as well as renal tubular injury. There is currently no available therapeutic for AKI. Previously, our group identified that serotonin (5-HT)
Identifiants
pubmed: 36326468
doi: 10.1152/ajprenal.00249.2022
pmc: PMC9762961
doi:
Substances chimiques
lasmiditan
760I9WM792
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
F56-F63Subventions
Organisme : BLRD VA
ID : I01 BX000851
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007091
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM139779
Pays : United States
Références
Q J Med. 1988 Feb;66(250):97-115
pubmed: 3051085
Fibrogenesis Tissue Repair. 2014 Mar 28;7(1):4
pubmed: 24678881
Cells. 2020 Feb 01;9(2):
pubmed: 32024113
Curr Neurol Neurosci Rep. 2009 May;9(3):212-9
pubmed: 19348710
Front Physiol. 2019 Feb 26;10:153
pubmed: 30873045
N Engl J Med. 2014 Jul 3;371(1):58-66
pubmed: 24988558
Neuropsychiatr Dis Treat. 2014 Mar 31;10:547-52
pubmed: 24729708
Compr Physiol. 2012 Apr;2(2):1303-53
pubmed: 23798302
Annu Rev Physiol. 2013;75:479-501
pubmed: 23140368
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15874-15883
pubmed: 32571916
Korean J Pediatr. 2010 Jul;53(7):735-40
pubmed: 21189948
Biol Pharm Bull. 2013;36(9):1391
pubmed: 23995646
Circ Res. 2012 Jul 20;111(3):278-89
pubmed: 22693349
Transl Res. 2015 Apr;165(4):512-30
pubmed: 25176603
J Pharmacol Exp Ther. 2017 Dec;363(3):419-427
pubmed: 29074644
Redox Biol. 2014 Jun 02;2:702-14
pubmed: 24944913
J Clin Invest. 2011 Oct;121(10):4003-14
pubmed: 21881206
J Clin Invest. 1989 Oct;84(4):1334-9
pubmed: 2551926
Nature. 2016 Mar 24;531(7595):528-32
pubmed: 26982719
J Am Soc Nephrol. 2003 Aug;14(8):2199-210
pubmed: 12874476
Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1119-F1128
pubmed: 29846105
Annu Rev Pharmacol Toxicol. 2016;56:229-49
pubmed: 26566156
Arch Intern Med. 2011 Feb 14;171(3):226-33
pubmed: 21325112
J Vis Exp. 2018 Sep 12;(139):
pubmed: 30272649
J Clin Med. 2020 Jun 25;9(6):
pubmed: 32630452
Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F853-64
pubmed: 22160772
Kidney Int. 2017 Jan;91(1):70-85
pubmed: 27678159
J Pharmacol Exp Ther. 2014 Aug;350(2):257-64
pubmed: 24849926
Am J Physiol Renal Physiol. 2006 Jan;290(1):F20-34
pubmed: 16339962
Exp Neurol. 2021 Jul;341:113720
pubmed: 33848513
Biochem Pharmacol. 2019 Nov;169:113644
pubmed: 31542386
J Am Soc Nephrol. 2018 Jul;29(7):1900-1916
pubmed: 29925521
Arch Intern Med. 1987 Jul;147(7):1213-8
pubmed: 3300586
J Am Soc Nephrol. 2022 Jan;33(1):15-32
pubmed: 34789545
N Engl J Med. 1996 May 30;334(22):1448-60
pubmed: 8618585
Kidney Int. 1974 Jul;6(1):24-37
pubmed: 4421857
J Investig Med. 1995 Oct;43(5):431-42
pubmed: 8528754
Nephron. 2021;145(3):297-310
pubmed: 33744890
Nat Rev Nephrol. 2017 Oct;13(10):629-646
pubmed: 28804120
Int J Mol Med. 2014 Dec;34(6):1451-7
pubmed: 25319473
Kidney Int. 2003 Aug;64(2):480-92
pubmed: 12846743
Nephrol Dial Transplant. 1997 Sep;12(9):1883-9
pubmed: 9306339
Lab Invest. 2021 Jul;101(7):851-864
pubmed: 33859334
Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F260-F268
pubmed: 29046298
Int J Mol Sci. 2019 Oct 06;20(19):
pubmed: 31590461