Microglia states and nomenclature: A field at its crossroads.
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
02 11 2022
02 11 2022
Historique:
received:
15
03
2022
revised:
06
08
2022
accepted:
12
10
2022
entrez:
3
11
2022
pubmed:
4
11
2022
medline:
8
11
2022
Statut:
ppublish
Résumé
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
Identifiants
pubmed: 36327895
pii: S0896-6273(22)00953-9
doi: 10.1016/j.neuron.2022.10.020
pmc: PMC9999291
mid: NIHMS1877689
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3458-3483Subventions
Organisme : NINDS NIH HHS
ID : R35 NS111582
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG060748
Pays : United States
Organisme : Medical Research Council
ID : MR/V032925/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : RF1 AG068558
Pays : United States
Organisme : Medical Research Council
ID : MR/P024572/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/N50192X/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH118329
Pays : United States
Organisme : Chief Scientist Office
ID : CGA/18/46
Pays : United Kingdom
Organisme : Parkinson's UK
ID : J-0901
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS106721
Pays : United States
Organisme : Medical Research Council
ID : MR/V031260/1
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests B.A. is the shareholder and member of scientific advisory board of Tranquis Therapeutics. K.B. is an employee and shareholder of AbbVie. M.C. receives research support from Vigil, is a member of the scientific advisory board of Vigil, and has a patent on TREM2. S.C. is a recipient of research funding from Eli Lilly and Company. C.C. is a member of the advisory board of Exalys Therapeutics and is the recipient of a research grant from IONIS therapeutics. B.D.S. is occasionally consulting for different companies. He is founding scientist of Augustin TX and of Muna TX. He is also shareholder of Muna TX. C.H. collaborates with Denali Therapeutics. C.H. is chief advisor of ISAR Bioscience and a member of the advisory board of AviadoBio. J.K. is a scientific advisor and collaborator with PureTech. T.M. is a cofounder of REGAIN Therapeutics, owner of a provisional patent on compositions and methods for treatment and/or prophylaxis of proteinopathies, and owner of a provisional patent on preventing or reverting abnormal amyloid deposition. R.M. has scientific collaborations with Alector, Nodthera, and Alchemab and is a consultant for Sanofi. B.M. has received consultancy fees from AstraZeneca. A. Sierra is a recipient of a research grant from Hoffmann La Roche.
Références
Elife. 2020 Jun 23;9:
pubmed: 32573436
Trends Neurosci. 2019 Nov;42(11):778-792
pubmed: 31635851
Nat Commun. 2020 Feb 5;11(1):735
pubmed: 32024846
PLoS Biol. 2019 Feb 8;17(2):e3000134
pubmed: 30735499
Neuron. 2019 Jan 16;101(2):207-223.e10
pubmed: 30606613
Brain Res. 1998 Dec 14;814(1-2):13-25
pubmed: 9838024
J Exp Med. 2019 Jan 7;216(1):41-59
pubmed: 30385457
Trends Genet. 2022 Feb;38(2):128-139
pubmed: 34561102
Nat Commun. 2021 Dec 8;12(1):7122
pubmed: 34880260
Neurobiol Dis. 2013 Jun;54:239-51
pubmed: 23313316
Brain Res. 2019 May 1;1710:220-229
pubmed: 30615888
J Pharmacol Exp Ther. 2020 Oct;375(1):202-209
pubmed: 32114512
Clin Chem. 2009 Apr;55(4):611-22
pubmed: 19246619
J Comp Neurol. 1991 Dec 1;314(1):125-35
pubmed: 1797868
J Mol Biol. 2017 Sep 1;429(18):2780-2789
pubmed: 28782559
Trends Immunol. 2015 Oct;36(10):569-577
pubmed: 26431936
J Neurosci. 2011 Nov 9;31(45):16241-50
pubmed: 22072675
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
J Neurosci Methods. 2007 Aug 30;164(2):207-17
pubmed: 17553569
Nat Commun. 2020 Mar 27;11(1):1577
pubmed: 32221280
J Neuroinflammation. 2021 Mar 17;18(1):74
pubmed: 33731174
Immunity. 2020 Nov 17;53(5):1033-1049.e7
pubmed: 33049219
Cell Rep. 2018 Sep 4;24(10):2773-2783.e6
pubmed: 30184509
Nat Neurosci. 2016 Mar;19(3):504-16
pubmed: 26780511
Brain Behav Immun. 2015 Aug;48:205-21
pubmed: 25843371
Nat Neurosci. 2007 Nov;10(11):1387-94
pubmed: 17965659
Sci Transl Med. 2021 Oct 13;13(615):eabe5640
pubmed: 34644146
Methods Mol Biol. 2019;2034:13-26
pubmed: 31392674
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
Nat Med. 2020 Jan;26(1):131-142
pubmed: 31932797
Front Immunol. 2019 Sep 20;10:2199
pubmed: 31616414
Nat Protoc. 2012 Jul 26;7(8):1534-50
pubmed: 22836135
Nature. 2022 Apr;604(7907):740-748
pubmed: 35444273
Immunity. 2019 Jan 15;50(1):253-271.e6
pubmed: 30471926
Cell Rep. 2018 Jul 3;24(1):130-141
pubmed: 29972775
Cell. 2020 Nov 12;183(4):1103-1116.e20
pubmed: 33098772
Cell Rep. 2019 Apr 23;27(4):1293-1306.e6
pubmed: 31018141
J Neurosci. 2005 Oct 5;25(40):9275-84
pubmed: 16207887
Cell Discov. 2018 Feb 27;4:9
pubmed: 29507754
Blood. 2003 Feb 1;101(3):1155-63
pubmed: 12393599
F1000Prime Rep. 2014 Mar 03;6:13
pubmed: 24669294
Nat Immunol. 2016 Jul;17(7):797-805
pubmed: 27135602
Stem Cell Reports. 2018 Jan 9;10(1):1-6
pubmed: 29320760
Brain Res. 2009 Apr 17;1266:29-36
pubmed: 19249294
PLoS Biol. 2020 Oct 8;18(10):e3000859
pubmed: 33031383
Cell. 2013 Dec 19;155(7):1596-609
pubmed: 24360280
Front Cell Neurosci. 2014 Aug 15;8:240
pubmed: 25177273
Nat Neurosci. 2019 Jan;22(1):78-90
pubmed: 30559476
J Neuroimmunol. 2009 May 29;210(1-2):3-12
pubmed: 19269040
Neuro Oncol. 2022 Jan 5;24(1):14-26
pubmed: 34043012
Am J Hum Genet. 2019 May 2;104(5):925-935
pubmed: 30982609
Trends Neurosci. 2016 Jun;39(6):378-393
pubmed: 27083478
Front Aging Neurosci. 2022 Mar 31;14:868448
pubmed: 35431903
Science. 2012 Apr 6;336(6077):86-90
pubmed: 22442384
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8257-62
pubmed: 21536909
Mol Cell. 2015 May 21;58(4):610-20
pubmed: 26000846
Nature. 2016 Apr 14;532(7598):240-244
pubmed: 27049947
Nat Rev Immunol. 2014 Aug;14(8):571-8
pubmed: 25033907
Clin Chem. 2020 Aug 1;66(8):1012-1029
pubmed: 32746458
Neuron. 2018 Jan 17;97(2):299-312.e6
pubmed: 29290552
PLoS One. 2013 Aug 19;8(8):e72083
pubmed: 23977213
Immunity. 2021 Jan 12;54(1):176-190.e7
pubmed: 33333014
Nat Neurosci. 2018 Aug;21(8):1049-1060
pubmed: 30038282
Nat Rev Neurol. 2019 Dec;15(12):704-717
pubmed: 31527807
Nat Commun. 2018 Dec 6;9(1):5206
pubmed: 30523248
J Neurosci. 2015 Apr 22;35(16):6532-43
pubmed: 25904803
Immunity. 2015 Jul 21;43(1):92-106
pubmed: 26163371
J Histochem Cytochem. 1991 May;39(5):561-8
pubmed: 1707903
Glia. 2016 Nov;64(11):1801-40
pubmed: 27634048
Cell. 2020 Aug 6;182(3):625-640.e24
pubmed: 32702313
Immunity. 2017 Sep 19;47(3):566-581.e9
pubmed: 28930663
Cell Metab. 2021 Nov 2;33(11):2260-2276.e7
pubmed: 34731656
Science. 2020 Jul 31;369(6503):530-537
pubmed: 32732419
Neuroscience. 1990;39(1):151-70
pubmed: 2089275
Nature. 2018 Apr;556(7701):332-338
pubmed: 29643512
Neuron. 2017 Oct 11;96(2):313-329.e6
pubmed: 29024657
J Neurosci. 2009 Apr 1;29(13):3974-80
pubmed: 19339593
Science. 2010 Nov 5;330(6005):783-8
pubmed: 21051630
Nat Neurosci. 2019 Dec;22(12):2111-2116
pubmed: 31659342
Nat Neurosci. 2020 Feb;23(2):194-208
pubmed: 31959936
Cell. 2017 Aug 10;170(4):649-663.e13
pubmed: 28802038
Nat Immunol. 2012 Nov;13(11):1118-28
pubmed: 23023392
Nat Neurosci. 2013 Dec;16(12):1896-905
pubmed: 24162652
Nat Neurosci. 2018 Apr;21(4):541-551
pubmed: 29507414
EMBO Rep. 2017 Jul;18(7):1186-1198
pubmed: 28483841
Nat Neurosci. 2014 Jan;17(1):131-43
pubmed: 24316888
PLoS Biol. 2016 May 26;14(5):e1002466
pubmed: 27228556
Neuropathology. 2016 Feb;36(1):39-49
pubmed: 26250788
Immunol Allergy Clin North Am. 2009 May;29(2):247-64
pubmed: 19389580
Nat Biotechnol. 2021 Jul;39(7):825-835
pubmed: 33846645
Sci Rep. 2015 Jun 08;5:10775
pubmed: 26053859
Cell. 2019 Jun 13;177(7):1873-1887.e17
pubmed: 31178122
Glia. 2019 Aug;67(8):1496-1509
pubmed: 30983036
J Neurosci Res. 2005 Aug 1;81(3):357-62
pubmed: 15948177
Brain Pathol. 2020 Nov;30(6):1178-1191
pubmed: 33058349
Nature. 2021 Sep;597(7878):709-714
pubmed: 34497421
Science. 2010 Nov 5;330(6005):841-5
pubmed: 20966214
Cell Rep. 2022 Jun 14;39(11):110961
pubmed: 35705056
EMBO J. 2020 Nov 16;39(22):e104464
pubmed: 32959911
Curr Protoc Mol Biol. 2015 Jan 05;109:21.29.1-21.29.9
pubmed: 25559105
Front Neuroanat. 2015 Apr 14;9:45
pubmed: 25926775
Science. 2019 Jan 25;363(6425):
pubmed: 30679343
J Comp Neurol. 1984 Jul 1;226(3):421-33
pubmed: 6747031
Nat Commun. 2019 Jul 19;10(1):3215
pubmed: 31324781
Nat Immunol. 2021 May;22(5):586-594
pubmed: 33859405
Cell. 2018 Jan 25;172(3):500-516.e16
pubmed: 29275859
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15558-63
pubmed: 18809917
Neuron. 2021 Apr 7;109(7):1100-1117.e10
pubmed: 33606969
STAR Protoc. 2021 Jun 11;2(2):100613
pubmed: 34179837
Science. 2017 Jun 23;356(6344):
pubmed: 28546318
Nat Neurosci. 2017 Jun;20(6):793-803
pubmed: 28414331
Dev Cell. 2015 Sep 28;34(6):632-41
pubmed: 26418294
Brain Res Dev Brain Res. 1999 Nov 18;117(2):145-52
pubmed: 10567732
J Histochem Cytochem. 1994 Aug;42(8):1033-41
pubmed: 8027523
Brain. 2017 Jul 1;140(7):1900-1913
pubmed: 28541408
J Immunol. 2016 Apr 15;196(8):3375-84
pubmed: 26962228
Neuron. 2019 Apr 17;102(2):435-449.e6
pubmed: 30827729
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Glia. 2016 May;64(5):826-39
pubmed: 26847266
Nat Commun. 2018 Jan 8;9(1):75
pubmed: 29311541
Neuron Glia Biol. 2011 Feb;7(1):67-76
pubmed: 22418067
Nat Neurosci. 2007 Dec;10(12):1538-43
pubmed: 18026097
J Exp Med. 2019 Oct 7;216(10):2265-2281
pubmed: 31350310
Acta Neuropathol Commun. 2019 Dec 11;7(1):206
pubmed: 31829283
Int J Mol Sci. 2020 Oct 26;21(21):
pubmed: 33114694
Glia. 2017 Sep;65(9):1504-1520
pubmed: 28618077
Nat Neurosci. 2020 Dec;23(12):1456-1468
pubmed: 32839617
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Nat Neurosci. 2018 Apr;21(4):530-540
pubmed: 29472620
Front Cell Neurosci. 2020 Nov 11;14:592214
pubmed: 33304243
Exp Neurol. 2020 Jul;329:113310
pubmed: 32289316
Nat Neurosci. 2021 Mar;24(3):312-325
pubmed: 33589835
J Neurosci. 2008 Sep 10;28(37):9133-44
pubmed: 18784294
J Neuropathol Exp Neurol. 2007 Aug;66(8):698-710
pubmed: 17882014
Mol Brain. 2019 Aug 19;12(1):71
pubmed: 31426845
Am J Hum Genet. 2019 May 2;104(5):936-947
pubmed: 30982608
Brain. 2022 Apr 29;145(3):964-978
pubmed: 34919646
Neuron. 2019 Sep 25;103(6):1016-1033.e10
pubmed: 31375314
BMC Dev Biol. 2009 Dec 21;9:70
pubmed: 20025746
J Immunol. 2000 Jun 15;164(12):6166-73
pubmed: 10843666
Nat Commun. 2020 Oct 23;11(1):5370
pubmed: 33097708
Neuron. 2018 Jun 27;98(6):1170-1183.e8
pubmed: 29861285
iScience. 2019 Jun 28;16:298-311
pubmed: 31203186
Nat Immunol. 2020 Jul;21(7):802-815
pubmed: 32541832
Nat Commun. 2020 Nov 30;11(1):6129
pubmed: 33257666
J Exp Med. 2021 Sep 6;218(9):
pubmed: 34292312
Science. 2016 Aug 19;353(6301):aad8670
pubmed: 27338705
Cell Rep. 2018 Jun 19;23(12):3501-3511
pubmed: 29924994
Nat Med. 2001 Dec;7(12):1356-61
pubmed: 11726978
Cell Stem Cell. 2010 Oct 8;7(4):483-95
pubmed: 20887954
Cell Rep. 2013 Jul 25;4(2):385-401
pubmed: 23850290
PLoS Biol. 2010 Nov 02;8(11):e1000527
pubmed: 21072242
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
J Exp Med. 2018 Jun 4;215(6):1627-1647
pubmed: 29643186
Nat Neurosci. 2005 Jun;8(6):752-8
pubmed: 15895084
Neuron. 2017 Jul 19;95(2):341-356.e6
pubmed: 28689984
Front Cell Neurosci. 2014 May 13;8:129
pubmed: 24860431
Cell Rep. 2020 Jun 30;31(13):107843
pubmed: 32610143
Brain Res Mol Brain Res. 1998 Jun 1;57(1):1-9
pubmed: 9630473
Brain Behav Immun. 2014 Nov;42:50-9
pubmed: 24858659
Glia. 2016 Sep;64(9):1562-72
pubmed: 27404378
Nat Commun. 2016 Mar 07;7:10905
pubmed: 26948129
Biotechnol Adv. 2021 Jul-Aug;49:107739
pubmed: 33794304
eNeuro. 2019 Aug 26;6(4):
pubmed: 31371457
J Immunol. 2020 Dec 1;205(11):3154-3166
pubmed: 33139489
EMBO Rep. 2018 Nov;19(11):
pubmed: 30206190
Nat Neurosci. 2013 Mar;16(3):273-80
pubmed: 23334579
Immunity. 2022 Aug 9;55(8):1448-1465.e6
pubmed: 35931085
Front Cell Neurosci. 2013 Mar 18;7:26
pubmed: 23507975
Acta Neuropathol Commun. 2021 Jan 5;9(1):1
pubmed: 33402227
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1738-46
pubmed: 26884166
Cell. 2019 Dec 12;179(7):1609-1622.e16
pubmed: 31835035
J Neuroinflammation. 2022 Sep 27;19(1):235
pubmed: 36167544
Immunology. 1986 Feb;57(2):239-47
pubmed: 3512425
Acta Neuropathol. 2021 May;141(5):681-696
pubmed: 33609158
Trends Immunol. 2020 Sep;41(9):771-784
pubmed: 32792173
Nat Neurosci. 2019 Jun;22(6):1021-1035
pubmed: 31061494
Biochem Biophys Res Commun. 1996 Jul 25;224(3):855-62
pubmed: 8713135
Glia. 1988;1(5):301-7
pubmed: 2976393
EMBO J. 2019 Sep 2;38(17):e101997
pubmed: 31373067
FEBS J. 2022 Sep;289(17):5049-5073
pubmed: 34145972
Mol Cell Biol. 2000 Jun;20(11):4106-14
pubmed: 10805752
Mol Cell. 2016 Jan 7;61(1):170-80
pubmed: 26687680
Nature. 2019 Feb;566(7744):388-392
pubmed: 30760929
STAR Protoc. 2021 Jul 07;2(3):100666
pubmed: 34286294
Front Immunol. 2018 Oct 01;9:2246
pubmed: 30327653
JAMA Neurol. 2021 Jan 1;78(1):102-113
pubmed: 33074286
Mol Syst Biol. 2019 Jun 19;15(6):e8746
pubmed: 31217225
Front Synaptic Neurosci. 2017 May 10;9:9
pubmed: 28539882
J Cell Biol. 1983 Jul;97(1):253-7
pubmed: 6345555
Brain Pathol. 2018 Sep;28(5):595-602
pubmed: 28987033
Neurobiol Aging. 2017 Apr;52:98-105
pubmed: 28131016
J Vis Exp. 2019 Oct 27;(152):
pubmed: 31710033
Cell. 2018 Oct 4;175(2):458-471.e19
pubmed: 30173917
Immunobiology. 1982 Apr;161(3-4):246-54
pubmed: 7047372
Glia. 2004 Jan 15;45(2):208-12
pubmed: 14730714
Nat Neurosci. 2022 Mar;25(3):306-316
pubmed: 35260865
Science. 2005 May 27;308(5726):1314-8
pubmed: 15831717
Nat Neurosci. 2016 Jul 26;19(8):987-91
pubmed: 27459405
Nat Neurosci. 2006 Dec;9(12):1512-9
pubmed: 17115040
Eur J Immunol. 2020 Mar;50(3):353-362
pubmed: 31762013
Cell Rep. 2020 Aug 11;32(6):108041
pubmed: 32783928