Decreased lifespan in female "Munchkin" actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity.

Female Humans Male Dwarfism, Pituitary Growth Hormone Human Growth Hormone Longevity Motion Pictures
Dwarfism Munchkin The Wizard of Oz

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
10 2022
Historique:
received: 08 09 2022
accepted: 21 10 2022
pubmed: 6 11 2022
medline: 23 12 2022
entrez: 5 11 2022
Statut: ppublish

Résumé

In laboratory mice, pituitary dwarfism caused by genetic reduction or elimination of the activity of growth hormone (GH) significantly extends lifespan. The effects of congenital pituitary dwarfism on human longevity are not well documented. To analyse the effects of untreated pituitary dwarfism on human lifespan, the longevity of a diverse group of widely known little people, the 124 adults who played "Munchkins" in the 1939 movie The Wizard of Oz was investigated. Survival of "Munchkin" actors with those of controls defined as cast members of The Wizard of Oz and those of other contemporary Academy Award winning Hollywood movies was compared. According to the Kaplan-Meier survival curves, survival of female and male "Munchkin" actors was shorter than cast controls and Hollywood controls of respective sexes. Cox regression analyses showed that female "Munchkin" actors had significantly higher risk ratios compared to both female cast controls (RR, 1.70; 95% CI, 1.05 to 2.77) and female Hollywood controls (RR, 1.52; 95% CI, 1.03 to 2.24). Similar trends were also discernible for men, albeit point estimates were not significant. The lack of lifespan extension in "Munchkin" actors does not support the hypothesis that hereditary GH deficiency regulates longevity in humans.

Identifiants

DOI: 10.1007/s11357-022-00680-7 PMID: 36334178 PMC: PMC9768075
pubmed: 36334178
doi: 10.1007/s11357-022-00680-7
pii: 10.1007/s11357-022-00680-7
pmc: PMC9768075
doi:

Substances chimiques

Growth Hormone 9002-72-6
Human Growth Hormone 12629-01-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2527-2539

Subventions

Organisme : NIA NIH HHS
ID : R01 AG038747
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG072295
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG050911
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052363
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA255840
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG011370
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG068295
Pays : United States
Organisme : Medical Research Council
ID : MR/S011676/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : K01 AG073614
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG070915
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to American Aging Association.

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Auteurs

Vince Fazekas-Pongor (V)

Department of Public Health, Semmelweis University, Budapest, Hungary.
ORCID: 0000-0002-6405-4003

Anna Péterfi (A)

Department of Public Health, Semmelweis University, Budapest, Hungary.

Dávid Major (D)

Department of Public Health, Semmelweis University, Budapest, Hungary.

Zsófia Szarvas (Z)

Department of Public Health, Semmelweis University, Budapest, Hungary.

Monika Fekete (M)

Department of Public Health, Semmelweis University, Budapest, Hungary.

Adam G Tabak (AG)

Department of Public Health, Semmelweis University, Budapest, Hungary.
Department of Epidemiology and Public Health, University College London, London, UK.
Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.

Anna Csiszar (A)

Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1313, Oklahoma City, OK, 731042, USA.
Vascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 731042, USA.
Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Departments of Translational Medicine and Public Health, Semmelweis University, Budapest, Hungary.

William E Sonntag (WE)

Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1313, Oklahoma City, OK, 731042, USA.

Steven N Austad (SN)

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Zoltan I Ungvari (ZI)

Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1313, Oklahoma City, OK, 731042, USA. zoltan-ungvari@ouhsc.edu.
Vascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 731042, USA. zoltan-ungvari@ouhsc.edu.
Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. zoltan-ungvari@ouhsc.edu.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Departments of Translational Medicine and Public Health, Semmelweis University, Budapest, Hungary. zoltan-ungvari@ouhsc.edu.
Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. zoltan-ungvari@ouhsc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Decreased lifespan in female "Munchkin" actors...
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Hypopituitarisme › Nanisme hypophysaire › Decreased lifespan in female "Munchkin" actors...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Hormone de croissance › Decreased lifespan in female "Munchkin" actors...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Hormone de croissance › Hormone de croissance humaine › Decreased lifespan in female "Munchkin" actors...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Decreased lifespan in female "Munchkin" actors...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Moyens de communication › Matériel d'enseignement › Supports audiovisuels › Films › Decreased lifespan in female "Munchkin" actors...