Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH.
Chemokines
Fatty liver disease
Group VIA phospholipase A2
Liver fibrosis
Tissue-specific gene deletion
de novo lipogenesis
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
13
07
2022
revised:
25
10
2022
accepted:
25
10
2022
pubmed:
6
11
2022
medline:
23
11
2022
entrez:
5
11
2022
Statut:
ppublish
Résumé
Polymorphisms of phospholipase A2VIA (iPLA2β or PLA2G6) are associated with body weights and blood C-reactive protein. The role of iPLA2β/PLA2G6 in non-alcoholic steatohepatitis (NASH) is still elusive because female iPla2β-null mice showed attenuated hepatic steatosis but exacerbated hepatic fibrosis after feeding with methionine- and choline-deficient diet (MCDD). Herein, female mice with myeloid- (MPla2g6
Identifiants
pubmed: 36334837
pii: S0925-4439(22)00261-7
doi: 10.1016/j.bbadis.2022.166590
pii:
doi:
Substances chimiques
Phospholipases A2, Calcium-Independent
EC 3.1.1.4
PPAR gamma
0
Interleukin-6
0
Lipopolysaccharides
0
Methionine
AE28F7PNPL
Choline
N91BDP6H0X
Racemethionine
73JWT2K6T3
PPAR alpha
0
Receptors, Chemokine
0
Pla2g6 protein, mouse
EC 3.1.1.4
Group VI Phospholipases A2
EC 3.1.1.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
166590Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare no competing interest.