Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort.
effort
glutathione
human
motivation
neuroscience
nucleus accumbens
rat
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 Nov 2022
08 Nov 2022
Historique:
received:
10
02
2022
accepted:
17
10
2022
entrez:
8
11
2022
pubmed:
9
11
2022
medline:
10
11
2022
Statut:
epublish
Résumé
Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant levels in the nucleus accumbens contribute to motivated performance is not known. Here, we identify a critical role for glutathione (GSH), the most important endogenous antioxidant in the brain, in motivation. Using proton magnetic resonance spectroscopy at ultra-high field in both male humans and rodent populations, we establish that higher accumbal GSH levels are highly predictive of better, and particularly, steady performance over time in effort-related tasks. Causality was established in
Identifiants
pubmed: 36345724
doi: 10.7554/eLife.77791
pii: 77791
pmc: PMC9642999
doi:
pii:
Substances chimiques
Antioxidants
0
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Zalachoras, Ramos-Fernández et al.
Déclaration de conflit d'intérêts
IZ, ER, FH, JR, AS, OZ, LX, SA, CS No competing interests declared, LT LT is employee from Nestle S.A, PS PS is employee from Nestle S.A, NP NP is employee from Nestle S.A
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