Anorexia nervosa as a disorder of the subcortical-cortical interoceptive-self.
Anorexia nervosa
Interoception
Resting-state functional connectivity
Self-objectification
Task-induced activity
fMRI
Journal
Eating and weight disorders : EWD
ISSN: 1590-1262
Titre abrégé: Eat Weight Disord
Pays: Germany
ID NLM: 9707113
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
26
09
2022
accepted:
03
11
2022
pubmed:
11
11
2022
medline:
4
1
2023
entrez:
10
11
2022
Statut:
ppublish
Résumé
Anorexia nervosa (AN) is characterized by a diminished capacity in perceiving the physiological correlates of interoceptive sensations, namely bodily self-consciousness. Given the neural division of self-processing into interoceptive-, exteroceptive- and mental-self, we hypothesize neural deficits in the interoceptive-processing regions in AN. To prove this, we reviewed resting state (rs), task and rest-task studies in AN literature. Neuronal data demonstrate the following in AN: (i) decreased rs-functional connectivity (rsFC) of subcortical-cortical midline structures (SCMS); (ii) reduced rsFC between medial (default-mode network/DMN and salience network/SN) and lateral (executive-control network/ECN) cortical regions; (iii) decreased rsFC in mainly the regions of the interoceptive-self; (iv) altered activity with overall increased activity in response to sensory/body image stimuli, especially in the regions of the interoceptive-self; (v) lack of a clear task-related distinction between own's and others' body image. These data may indicate that rs-hypoconnectivity between SCMS, as neural correlate of a reduced intero-exteroceptive integration resulting in self-objectification, might be linked to overall increased activity in interoceptive regions during sensory/body image stimuli in AN, engendering an "anxious bodily self." I: Systematic review.
Identifiants
pubmed: 36355249
doi: 10.1007/s40519-022-01510-7
pii: 10.1007/s40519-022-01510-7
pmc: PMC9803759
doi:
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3063-3081Subventions
Organisme : National Natural Science Foundation of China
ID : 31271195
Organisme : National Key Research and Development Program of China
ID : 2016YFC1306700
Organisme : European Union's Horizon 2020 Framework Program for Research and Innovation
ID : 785907
Informations de copyright
© 2022. The Author(s).
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