Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study.
Alzheimer’s disease
heparin
proline-rich region
tau
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
27 10 2022
27 10 2022
Historique:
received:
23
02
2021
revised:
06
10
2022
accepted:
09
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
(1) Background: Prion-like transcellular spreading of tau pathology in Alzheimer's disease (AD) is mediated by tau binding to the cell-surface glycan heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. (2) Methods and Results: Binding-site mapping using NMR showed two major binding regions in full-length tau responsible for heparin interaction. Thus, two tau constructs, tau PRR2* and tau R2*, were designed to investigate the molecular details at the tau-heparin binding interface. The 2D
Identifiants
pubmed: 36358923
pii: biom12111573
doi: 10.3390/biom12111573
pmc: PMC9687896
pii:
doi:
Substances chimiques
Fondaparinux
J177FOW5JL
Heparitin Sulfate
9050-30-0
Heparin
9005-49-6
Proline
9DLQ4CIU6V
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : 1RF1AG069039
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG057464
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144970
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG069039
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG066493
Pays : United States
Références
Glycobiology. 2014 Aug;24(8):681-92
pubmed: 24770491
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4376-85
pubmed: 25261551
J Biol Chem. 2009 May 8;284(19):12845-52
pubmed: 19282288
Brain. 2018 Feb 1;141(2):550-567
pubmed: 29293892
J Biol Chem. 2007 Apr 20;282(16):12230-9
pubmed: 17307736
Brain. 2017 Feb;140(2):266-278
pubmed: 27658420
J Cell Biol. 1991 Nov;115(3):717-30
pubmed: 1918161
Nat Med. 2014 Feb;20(2):130-8
pubmed: 24504409
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3138-47
pubmed: 23898162
Sci Rep. 2018 Apr 23;8(1):6382
pubmed: 29686391
J Biol Chem. 2013 Jan 18;288(3):1856-70
pubmed: 23188818
Nat Chem Biol. 2014 Apr;10(4):248-50
pubmed: 24561662
Biochemistry. 2006 Oct 17;45(41):12560-72
pubmed: 17029411
Neuron. 2012 Feb 23;73(4):685-97
pubmed: 22365544
Nat Rev Neurosci. 2015 Feb;16(2):109-20
pubmed: 25588378
Brain. 2015 May;138(Pt 5):1339-54
pubmed: 25842390
Biophys J. 2017 Mar 14;112(5):921-932
pubmed: 28297651
Cell. 2012 Mar 30;149(1):232-44
pubmed: 22464332
PLoS One. 2012;7(2):e31302
pubmed: 22312444
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006247
pubmed: 22762014
Nat Cell Biol. 2009 Jul;11(7):909-13
pubmed: 19503072
Biochemistry. 1994 Aug 16;33(32):9511-22
pubmed: 8068626
Angew Chem Int Ed Engl. 2020 Jan 27;59(5):1818-1827
pubmed: 31692167
Methods Mol Biol. 2017;1523:179-213
pubmed: 27975251
J Biol Chem. 2018 Jul 6;293(27):10826-10840
pubmed: 29752409
Protein Sci. 2013 Aug;22(8):1037-48
pubmed: 23740819
Nature. 1999 Jun 24;399(6738):784-8
pubmed: 10391244