Do reproductive history and information given through genetic counselling influence patients' decisions on mosaic embryo transfer?
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
04
10
2022
received:
16
03
2022
accepted:
10
11
2022
pubmed:
14
11
2022
medline:
16
12
2022
entrez:
13
11
2022
Statut:
ppublish
Résumé
To assess patients' and embryonic characteristics that may have an influence on the decision to transfer a mosaic embryo. Single centre retrospective cohort study including 1247 PGT-A cycles. Demographic and clinical factors associated with a decision to transfer a mosaic embryo were studied. Female age, number of previous cycles, previous availability of euploid embryos, history of miscarriages and parity as well as percentage of mosaicism, type of anomaly and chromosome risk were studied in relation to decision-making. Outcomes after mosaic embryo transfer were assessed. To date, in 7.9% of cycles (99/1247), patients have had to make a decision on the fate of their mosaic embryos. In 23.2% of cycles (23/99), patients decided to transfer. In most cases (79.8%; 79/99), patients underwent genetic counselling before the decision. None of the variables analysed were associated with the patients' decision, although parity and the high-degree mosaicism (>50%) seemed to be negatively associated with the decision to transfer (18.2% vs. 29.8%, p = 0.294; 10% vs. 32.2%, p = 0.052). Neither reproductive history nor information on mosaic embryo characteristics through counselling seems to be determinative for patients when deciding to transfer a mosaic embryo. Promising and increasing data on clinical outcomes after mosaic embryo transfer will be of utmost importance to soften risk perception regarding mosaic embryos and give a better, simplified and more evidence-based counselling.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1650-1657Informations de copyright
© 2022 John Wiley & Sons Ltd.
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