Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum.

Receptor, Adenosine A2A / metabolism Glutamic Acid Corpus Striatum / metabolism Receptors, Cannabinoid Adenosine Cholinergic Agents
Acetylcholine release Adenosine A(1) receptor Adenosine A(2A) receptor Dopamine release G protein-coupled receptor heteromers Glutamate release Parkinson's disease Restless legs syndrome Striatum

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 Feb 2023
Historique:
received: 10 10 2022
revised: 01 11 2022
accepted: 03 11 2022
pubmed: 15 11 2022
medline: 15 12 2022
entrez: 14 11 2022
Statut: ppublish

Résumé

Adenosine plays a very significant role in modulating striatal glutamatergic and dopaminergic neurotransmission. In the present essay we first review the extensive evidence that indicates this modulation is mediated by adenosine A

Identifiants

DOI: 10.1016/j.neuropharm.2022.109329 PMID: 36375695
pubmed: 36375695
pii: S0028-3908(22)00388-4
doi: 10.1016/j.neuropharm.2022.109329
pii:
doi:

Substances chimiques

Receptor, Adenosine A2A 0
Glutamic Acid 3KX376GY7L
Receptors, Cannabinoid 0
Adenosine K72T3FS567
Cholinergic Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

109329

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Sergi Ferré (S)

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Baltimore, MD, USA. Electronic address: sferre@intra.nida.nih.gov.

Laura I Sarasola (LI)

Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907, L'Hospitalet de Llobregat, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, 08907, L'Hospitalet de Llobregat, Spain.

César Quiroz (C)

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Baltimore, MD, USA.

Francisco Ciruela (F)

Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907, L'Hospitalet de Llobregat, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, 08907, L'Hospitalet de Llobregat, Spain. Electronic address: fciruela@ub.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteurs A2 à l'adénosine › Récepteur A2A à l'adénosine › Presynaptic adenosine receptor heteromers as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Presynaptic adenosine receptor heteromers as...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Presynaptic adenosine receptor heteromers as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Presynaptic adenosine receptor heteromers as...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Presynaptic adenosine receptor heteromers as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Presynaptic adenosine receptor heteromers as...