Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer.
Humans
Carcinoma, Squamous Cell
/ genetics
Microbiota
/ genetics
Mouth Neoplasms
/ genetics
Myeloid Cells
/ immunology
Tumor Microenvironment
Host Microbial Interactions
/ genetics
Colorectal Neoplasms
/ genetics
Sequence Analysis, RNA
Gene Expression Profiling
Ki-67 Antigen
/ metabolism
Disease Progression
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
09
03
2022
accepted:
10
10
2022
pubmed:
18
11
2022
medline:
26
11
2022
entrez:
17
11
2022
Statut:
ppublish
Résumé
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types
Identifiants
pubmed: 36385528
doi: 10.1038/s41586-022-05435-0
pii: 10.1038/s41586-022-05435-0
pmc: PMC9684076
doi:
Substances chimiques
Ki-67 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
810-817Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027850
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NIH HHS
ID : S10 OD028685
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA080416
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA229984
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
Références
Sepich-Poore, G. D. et al. The microbiome and human cancer. Science 371, eabc4552 (2021).
doi: 10.1126/science.abc4552
pubmed: 33766858
pmcid: 8767999
Nejman, D. et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368, 973–980 (2020).
doi: 10.1126/science.aay9189
pubmed: 32467386
pmcid: 7757858
Kostic, A. D. et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22, 292–298 (2012).
doi: 10.1101/gr.126573.111
pubmed: 22009990
pmcid: 3266036
Rao, A., Barkley, D., Franca, G. S. & Yanai, I. Exploring tissue architecture using spatial transcriptomics. Nature 596, 211–220 (2021).
doi: 10.1038/s41586-021-03634-9
pubmed: 34381231
pmcid: 8475179
Tang, F. et al. mRNA-seq whole-transcriptome analysis of a single cell. Nat. Methods 6, 377–382 (2009).
doi: 10.1038/nmeth.1315
pubmed: 19349980
Merritt, C. R. et al. Multiplex digital spatial profiling of proteins and RNA in fixed tissue. Nat. Biotechnol. 38, 586–599 (2020).
doi: 10.1038/s41587-020-0472-9
pubmed: 32393914
LaCourse, K. D., Johnston, C. D. & Bullman, S. The relationship between gastrointestinal cancers and the microbiota. Lancet Gastroenterol. Hepatol. 6, 498–509 (2021).
doi: 10.1016/S2468-1253(20)30362-9
pubmed: 33743198
Bullman, S. et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 358, 1443–1448 (2017).
doi: 10.1126/science.aal5240
pubmed: 29170280
pmcid: 5823247
Parhi, L. et al. Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression. Nat. Commun. 11, 3259 (2020).
doi: 10.1038/s41467-020-16967-2
pubmed: 32591509
pmcid: 7320135
Fu, A. et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell 185, 1356–1372 (2022).
doi: 10.1016/j.cell.2022.02.027
pubmed: 35395179
Jin, C. et al. Commensal microbiota promote lung cancer development via γδ T cells. Cell 176, 998–1013 (2019).
doi: 10.1016/j.cell.2018.12.040
pubmed: 30712876
pmcid: 6691977
Riquelme, E. et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell 178, 795–806 (2019).
doi: 10.1016/j.cell.2019.07.008
pubmed: 31398337
pmcid: 7288240
Kalaora, S. et al. Identification of bacteria-derived HLA-bound peptides in melanoma. Nature 592, 138–143 (2021).
doi: 10.1038/s41586-021-03368-8
pubmed: 33731925
pmcid: 9717498
Yu, T. et al. Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell 170, 548–563 (2017).
doi: 10.1016/j.cell.2017.07.008
pubmed: 28753429
pmcid: 5767127
Geller, L. T. et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science 357, 1156–1160 (2017).
doi: 10.1126/science.aah5043
pubmed: 28912244
pmcid: 5727343
Poore, G. D. et al. Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature 579, 567–574 (2020).
doi: 10.1038/s41586-020-2095-1
pubmed: 32214244
pmcid: 7500457
Walker, M. A. et al. GATK PathSeq: a customizable computational tool for the discovery and identification of microbial sequences in libraries from eukaryotic hosts. Bioinformatics 34, 4287–4289 (2018).
doi: 10.1093/bioinformatics/bty501
pubmed: 29982281
pmcid: 6289130
Van Ziffle, J. A. & Lowell, C. A. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114, 4871–4882 (2009).
doi: 10.1182/blood-2009-05-220806
pubmed: 19797524
pmcid: 2786293
Lara, R., Seckl, M. J. & Pardo, O. E. The p90 RSK family members: common functions and isoform specificity. Cancer Res. 73, 5301–5308 (2013).
doi: 10.1158/0008-5472.CAN-12-4448
pubmed: 23970478
Mima, K. et al. Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol. 1, 653–661 (2015).
doi: 10.1001/jamaoncol.2015.1377
pubmed: 26181352
pmcid: 4537376
Serna, G. et al. Fusobacterium nucleatum persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer. Ann. Oncol. 31, 1366–1375 (2020).
doi: 10.1016/j.annonc.2020.06.003
pubmed: 32569727
Pastushenko, I. & Blanpain, C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29, 212–226 (2019).
doi: 10.1016/j.tcb.2018.12.001
pubmed: 30594349
Muller, P. A. & Vousden, K. H. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell 25, 304–317 (2014).
doi: 10.1016/j.ccr.2014.01.021
pubmed: 24651012
pmcid: 3970583
Kienle, K. et al. Neutrophils self-limit swarming to contain bacterial growth in vivo. Science 372, eabe7729 (2021).
doi: 10.1126/science.abe7729
pubmed: 34140358
pmcid: 8926156
Oliveira, M. J. et al. β-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. EMBO J. 22, 6161–6173 (2003).
doi: 10.1093/emboj/cdg586
pubmed: 14609961
pmcid: 275444
Hatzikirou, H., Basanta, D., Simon, M., Schaller, K. & Deutsch, A. ‘Go or grow’: the key to the emergence of invasion in tumour progression? Math. Med. Biol. 29, 49–65 (2012).
doi: 10.1093/imammb/dqq011
pubmed: 20610469
Gallaher, J. A., Brown, J. S. & Anderson, A. R. A. The impact of proliferation–migration tradeoffs on phenotypic evolution in cancer. Sci. Rep. 9, 2425 (2019).
doi: 10.1038/s41598-019-39636-x
pubmed: 30787363
pmcid: 6382810
Wrenn, E. D. et al. Regulation of collective metastasis by nanolumenal signaling. Cell 183, 395–410 (2020).
doi: 10.1016/j.cell.2020.08.045
pubmed: 33007268
pmcid: 7772852
Dagogo-Jack, I. & Shaw, A. T. Tumour heterogeneity and resistance to cancer therapies. Nat. Rev. Clin. Oncol. 15, 81–94 (2018).
doi: 10.1038/nrclinonc.2017.166
pubmed: 29115304
van der Bruggen, P. et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254, 1643–1647 (1991).
doi: 10.1126/science.1840703
pubmed: 1840703
Dvorak, H. F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650–1659 (1986).
doi: 10.1056/NEJM198612253152606
pubmed: 3537791
Anderson, N. M. & Simon, M. C. The tumor microenvironment. Curr. Biol. 30, R921–R925 (2020).
doi: 10.1016/j.cub.2020.06.081
pubmed: 32810447
pmcid: 8194051
Joyce, J. A. & Fearon, D. T. T cell exclusion, immune privilege, and the tumor microenvironment. Science 348, 74–80 (2015).
doi: 10.1126/science.aaa6204
pubmed: 25838376
Kieffer, Y. et al. Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. Cancer Discov. 10, 1330–1351 (2020).
doi: 10.1158/2159-8290.CD-19-1384
pubmed: 32434947
Qian, J. et al. A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. Cell Res. 30, 745–762 (2020).
doi: 10.1038/s41422-020-0355-0
pubmed: 32561858
pmcid: 7608385
Wu, F. et al. Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nat. Commun. 12, 2540 (2021).
doi: 10.1038/s41467-021-22801-0
pubmed: 33953163
pmcid: 8100173
Pernigoni, N. et al. Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis. Science 374, 216–224 (2021).
doi: 10.1126/science.abf8403
pubmed: 34618582
Vickovic, S. et al. High-definition spatial transcriptomics for in situ tissue profiling. Nat. Methods 16, 987–990 (2019).
doi: 10.1038/s41592-019-0548-y
pubmed: 31501547
pmcid: 6765407
Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202–1214 (2015).
doi: 10.1016/j.cell.2015.05.002
pubmed: 26000488
pmcid: 4481139
Hunter, M. V., Moncada, R., Weiss, J. M., Yanai, I. & White, R. M. Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nat. Commun. 12, 6278 (2021).
doi: 10.1038/s41467-021-26614-z
pubmed: 34725363
pmcid: 8560802