Co-administration of FVIII with IVIG reduces immune response to FVIII in hemophilia A mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 11 2022
22 11 2022
Historique:
received:
20
12
2021
accepted:
03
05
2022
entrez:
23
11
2022
pubmed:
24
11
2022
medline:
26
11
2022
Statut:
epublish
Résumé
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in clinical management of the disease. Here, we investigated the effect of co-administration of FVIII with intravenous immunoglobulin (IVIG) on the development of inhibitors in previously untreated hemophilia A mice. A group of hemophilia A mice (C57BL/6
Identifiants
pubmed: 36418333
doi: 10.1038/s41598-022-19392-1
pii: 10.1038/s41598-022-19392-1
pmc: PMC9684572
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Factor VIII
9001-27-8
Antibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20074Informations de copyright
© 2022. The Author(s).
Références
Lancet. 2016 Jul 9;388(10040):187-97
pubmed: 26897598
Hematol Oncol Clin North Am. 2017 Oct;31(5):853-868
pubmed: 28895852
Nat Rev Immunol. 2013 Mar;13(3):176-89
pubmed: 23411799
Blood Coagul Fibrinolysis. 2015 Sep;26(6):604-12
pubmed: 25886836
Haemophilia. 2004 Jan;10(1):63-8
pubmed: 14962222
J Thromb Haemost. 2010 Dec;8(12):2743-50
pubmed: 20961391
Thromb Haemost. 2002 Aug;88(2):221-9
pubmed: 12195693
J Neuroinflammation. 2012 Oct 09;9:234
pubmed: 23046563
Blood. 2009 Jul 23;114(4):871-80
pubmed: 19411636
Eur J Immunol. 1988 Feb;18(2):313-6
pubmed: 3350037
Blood Rev. 2013 Jul;27(4):179-84
pubmed: 23815950
J Thromb Haemost. 2003 Jul;1(7):1349-55
pubmed: 12871268
Hematol Oncol Clin North Am. 2019 Jun;33(3):409-423
pubmed: 31030810
Haemophilia. 2006 Jul;12 Suppl 3:52-60
pubmed: 16683997
Clin Biochem Rev. 2008 Aug;29 Suppl 1:S49-52
pubmed: 18852857
Immunity. 2000 Dec;13(6):783-94
pubmed: 11163194
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
Curr Top Microbiol Immunol. 1973;60:125-74
pubmed: 4577505
Transfusion. 2014 Nov;54(11):2871-9
pubmed: 24826802
Pediatr Rev. 2013 Jul;34(7):289-94; quiz 295
pubmed: 23818083
J Neuroinflammation. 2014 Mar 22;11:54
pubmed: 24655894
Lancet. 2012 Apr 14;379(9824):1447-56
pubmed: 22456059
Haemophilia. 2019 Jul;25(4):545-557
pubmed: 31115117
Am J Hematol. 1998 Dec;59(4):288-94
pubmed: 9840909
Clin Rev Allergy Immunol. 2009 Oct;37(2):105-13
pubmed: 19165635
J Neurol. 2008 Jul;255 Suppl 3:3-6
pubmed: 18685919
Br J Haematol. 2015 Jun;169(6):768-76
pubmed: 25754016
J Diabetes Res. 2013;2013:621693
pubmed: 23710469
Transfusion. 2010 Jun;50(6):1285-94
pubmed: 20088841
Thromb Haemost. 1995 Feb;73(2):247-51
pubmed: 7792738
J Clin Immunol. 2013 Jan;33 Suppl 1:S43-9
pubmed: 22941509
Immunol Today. 1990 Jan;11(1):21-4
pubmed: 2405874
J Thromb Haemost. 2015 Jun;13 Suppl 1:S176-9
pubmed: 26149020
Autoimmun Rev. 2013 Jan;12(3):436-43
pubmed: 22944299
Blood. 2017 Nov 23;130(21):2251-2256
pubmed: 29018078
Thromb Haemost. 2007 May;97(5):788-94
pubmed: 17479189
Thromb Haemost. 2003 Jun;89(6):1110-2; author reply 1113
pubmed: 12783127
Blood. 2015 Mar 26;125(13):2045-51
pubmed: 25712994
Nature. 1988 Aug 18;334(6183):623-5
pubmed: 3261393
N Engl J Med. 2017 Aug 31;377(9):809-818
pubmed: 28691557
N Engl J Med. 2001 Sep 6;345(10):747-55
pubmed: 11547745
Transfus Med Rev. 2013 Jul;27(3):171-8
pubmed: 23835249
J Thromb Haemost. 2004 Jul;2(7):1082-95
pubmed: 15219191