Cell-intrinsic ceramides determine T cell function during melanoma progression.
T cells
ceramide
immunology
inflammation
melanoma
mouse
sphingolipids
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
25 11 2022
25 11 2022
Historique:
received:
31
08
2022
accepted:
15
11
2022
entrez:
25
11
2022
pubmed:
26
11
2022
medline:
29
11
2022
Statut:
epublish
Résumé
Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms that are involved in receptor clustering within cellular membranes. However, the impact of cell-intrinsic ceramide on T cell function is not well characterized. By using T cell-specific Asm- or Ac-deficient mice, with reduced or elevated ceramide levels in T cells, we identified ceramide to play a crucial role in T cell function in vitro and in vivo. T cell-specific ablation of Asm in
Identifiants
pubmed: 36426850
doi: 10.7554/eLife.83073
pii: 83073
pmc: PMC9699697
doi:
pii:
Substances chimiques
Ceramides
0
Sphingosine
NGZ37HRE42
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2022, Hose, Günther et al.
Déclaration de conflit d'intérêts
MH, AG, EN, FS, TS, JF, AP, BK, KB, EG, AH, JB, AW, WH No competing interests declared
Références
J Immunol. 2016 Oct 15;197(8):3130-3141
pubmed: 27638864
Lab Anim (NY). 2013 Jun;42(6):217-24
pubmed: 23689461
J Clin Med. 2021 Oct 28;10(21):
pubmed: 34768550
Nat Immunol. 2009 Jul;10(7):761-8
pubmed: 19525969
J Clin Oncol. 2007 Jun 20;25(18):2586-93
pubmed: 17577038
Cell Death Dis. 2015 Jul 23;6:e1828
pubmed: 26203857
Nat Genet. 1995 Jul;10(3):288-93
pubmed: 7670466
J Clin Invest. 2020 Oct 1;130(10):5461-5476
pubmed: 32663191
Front Immunol. 2019 May 31;10:1225
pubmed: 31214184
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713
Crit Rev Oncol Hematol. 2019 Jun;138:104-111
pubmed: 31092365
Cancer Res. 2004 Nov 15;64(22):8285-91
pubmed: 15548696
J Cell Physiol. 2000 Sep;184(3):285-300
pubmed: 10911359
Eur J Immunol. 2015 Jun;45(6):1654-66
pubmed: 25754875
Brain Commun. 2021 Mar 05;3(2):fcab020
pubmed: 33898989
J Immunol. 2006 Jul 15;177(2):896-904
pubmed: 16818744
Science. 2003 May 16;300(5622):1155-9
pubmed: 12750523
J Biol Chem. 2007 Apr 13;282(15):10922-34
pubmed: 17303574
Cell. 1994 Jan 14;76(1):17-27
pubmed: 8287475
Breast Cancer Res Treat. 2012 Jun;133(2):447-58
pubmed: 21935601
Nat Rev Cancer. 2013 Jan;13(1):51-65
pubmed: 23235911
Lancet Oncol. 2012 Jan;13(1):e32-42
pubmed: 22225723
J Immunol. 2003 Jul 1;171(1):27-31
pubmed: 12816979
Front Immunol. 2018 Apr 18;9:815
pubmed: 29720981
Cell Physiol Biochem. 2016;39(3):985-95
pubmed: 27512981
Cancer Immunol Immunother. 2020 Apr;69(4):611-627
pubmed: 31996991
Cell Rep. 2019 Aug 13;28(7):1879-1893.e7
pubmed: 31412253
J Lipid Res. 2020 Jun;61(6):896-910
pubmed: 32156719
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43
pubmed: 16344461
Cell. 1996 Jul 26;86(2):189-99
pubmed: 8706124
Cancer Immunol Res. 2015 Jun;3(6):631-40
pubmed: 25711759
Eur J Immunol. 2004 Mar;34(3):623-630
pubmed: 14991591
Cancer Res. 2014 Aug 15;74(16):4258-69
pubmed: 24906621
Front Physiol. 2014 Sep 02;5:331
pubmed: 25228885
Nat Rev Cancer. 2004 Aug;4(8):604-16
pubmed: 15286740
Genome Biol. 2015 Mar 31;16:64
pubmed: 25853550
Orphanet J Rare Dis. 2018 Jul 20;13(1):121
pubmed: 30029679
Mol Psychiatry. 2018 Dec;23(12):2324-2346
pubmed: 30038230
Nihon Rinsho. 1995 Dec;53(12):3014-8
pubmed: 8577051
Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191
pubmed: 29165427
Jpn J Clin Oncol. 2005 Sep;35(9):536-44
pubmed: 16155120
Biochim Biophys Acta. 2009 Jan;1788(1):178-83
pubmed: 18786504
Oncogene. 2003 Aug 21;22(35):5457-70
pubmed: 12934106
Best Pract Res Clin Endocrinol Metab. 2015 Mar;29(2):237-47
pubmed: 25987176
J Exp Med. 2012 Oct 22;209(11):2001-16
pubmed: 23045606
Nat Commun. 2011;2:282
pubmed: 21505438
Nat Med. 2013 Jul;19(7):934-8
pubmed: 23770692
PLoS Pathog. 2014 Dec 18;10(12):e1004574
pubmed: 25521388
J Neural Transm (Vienna). 2005 Nov;112(11):1583-90
pubmed: 16245071