Bio-membranes: Picosecond to second dynamics and plasticity as deciphered by solid state NMR.
Activation energy
Correlation time
Filter dynamics
Membrane elasticity
Membrane phase
Order parameter
Solid-state NMR
Journal
Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
07
10
2022
revised:
21
11
2022
accepted:
23
11
2022
pubmed:
29
11
2022
medline:
21
12
2022
entrez:
28
11
2022
Statut:
ppublish
Résumé
Since the first membrane models in the 1970s, the concept of biological membranes has evolved considerably. The membrane is now seen as a very complex mixture whose dynamic behavior is even more complex. Solid-state NMR is well suited for such studies as it can probe the movements of the membrane from picoseconds to seconds. Two NMR observables can be used: motionally averaged spectra and relaxation times. They bring information on order parameters, phase transitions, correlation times, activation energies and membrane elasticity. Spectra are used to determine the nature of the membrane phase. The order parameters can be measured directly from spectra that are dominated by quadrupolar, dipolar and chemical shielding magnetic interactions and allow describing the lipid membrane as being very rigid at the glycerol and chain level and very fluid at its center and surface. Correlation times and activation energies can be measured for intramolecular motions (pico to nanoseconds), molecular motions (nano to 100 ns) and collective modes of membrane deformation (microseconds). Sterols modulate membrane phases, order parameters, correlation times and membrane elasticity. In general terms, sterols tend to act to reduce the impact of environmental changes on molecular order and dynamics. They can be described as regulators of membrane dynamics by keeping them in a state of dynamics that changes very little when the temperature or other factors change. The presence of such large-scale membrane dynamics is proposed as a means of adapting to evolutionary constraints.
Identifiants
pubmed: 36442647
pii: S0005-2736(22)00235-8
doi: 10.1016/j.bbamem.2022.184097
pii:
doi:
Substances chimiques
Sterols
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
184097Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Erick J Dufourc reports financial support was provided by CNRS - University Bordeaux - Bordeaux INP. Erick J. Dufourc reports a relationship with University of Bordeaux, CNRS that includes: employment.