STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D

Animals Mice Autoimmune Diseases / genetics CD8-Positive T-Lymphocytes Gain of Function Mutation Leukemia, Large Granular Lymphocytic / genetics Mutation NK Cell Lectin-Like Receptor Subfamily K / genetics STAT3 Transcription Factor / genetics
CD8(+) T cells IL-15 NK-like NKG2D STAT3 autoimmune disease cytokine danger signals gain-of-function mutation leukemia

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
13 12 2022
Historique:
received: 21 03 2022
revised: 30 07 2022
accepted: 03 11 2022
pubmed: 30 11 2022
medline: 17 12 2022
entrez: 29 11 2022
Statut: ppublish

Résumé

The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8

Identifiants

DOI: 10.1016/j.immuni.2022.11.001 PMID: 36446385
pubmed: 36446385
pii: S1074-7613(22)00591-X
doi: 10.1016/j.immuni.2022.11.001
pii:
doi:

Substances chimiques

NK Cell Lectin-Like Receptor Subfamily K 0
STAT3 Transcription Factor 0
Stat3 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2386-2404.e8

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Etienne Masle-Farquhar (E)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia. Electronic address: e.masle-farquhar@garvan.org.au.

Katherine J L Jackson (KJL)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.

Timothy J Peters (TJ)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Ghamdan Al-Eryani (G)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Mandeep Singh (M)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Kathryn J Payne (KJ)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.

Geetha Rao (G)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.

Danielle T Avery (DT)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.

Gabrielle Apps (G)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; Australian BioResources, Moss Vale, NSW 2577, Australia.

Jennifer Kingham (J)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; Australian BioResources, Moss Vale, NSW 2577, Australia.

Christopher J Jara (CJ)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Ksenia Skvortsova (K)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Alexander Swarbrick (A)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Cindy S Ma (CS)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Daniel Suan (D)

Westmead Clinical School, The University of Sydney, Westmead, Sydney, NSW, Australia.

Gulbu Uzel (G)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.

Ignatius Chua (I)

Canterbury Health Laboratories, Christchurch, New Zealand.

Jennifer W Leiding (JW)

Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, Tampa, FL, USA; Division of Allergy and Immunology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.

Kaarina Heiskanen (K)

Children's Immunodeficiency Unit, Hospital for Children and Adolescents, and Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Kahn Preece (K)

Department of Immunology, John Hunter Children's Hospital, Newcastle, NSW, Australia.

Leena Kainulainen (L)

Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.

Michael O'Sullivan (M)

Immunology Department, Fiona Stanley Hospital, Murdoch, WA, Australia.

Megan A Cooper (MA)

Department of Pedatrics, Division of Rheumatology/Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Mikko R J Seppänen (MRJ)

Rare Disease and Pediatric Research Centers, Hospital for Children and Adolescents, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Satu Mustjoki (S)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.

Shannon Brothers (S)

Starship Children's Hospital, Auckland, New Zealand.

Tiphanie P Vogel (TP)

Department of Pedatrics, Division of Rheumatology/Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Robert Brink (R)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Stuart G Tangye (SG)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Joanne H Reed (JH)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; School of Clinical Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

Christopher C Goodnow (CC)

The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; Cellular Genomics Futures Institute, UNSW Sydney, Sydney, NSW, Australia. Electronic address: c.goodnow@garvan.org.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation gain de fonction › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie à cellules T › Leucémie à grands lymphocytes granuleux › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de cellules tueuses naturelles › Récepteurs de cellules NK de type lectine › Sous-famille K des récepteurs de cellules NK de type lectine › STAT3 gain-of-function mutations connect...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › STAT3 gain-of-function mutations connect...