Neonatal motor functional connectivity and motor outcomes at age two years in very preterm children with and without high-grade brain injury.
Brain injury
Cerebral palsy
Functional connectivity
Motor cortex
Preterm birth
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
06
2022
revised:
09
10
2022
accepted:
02
11
2022
pubmed:
2
12
2022
medline:
15
12
2022
entrez:
1
12
2022
Statut:
ppublish
Résumé
Preterm-born children have high rates of motor impairments, but mechanisms for early identification remain limited. We hypothesized that neonatal motor system functional connectivity (FC) would relate to motor outcomes at age two years; currently, this relationship is not yet well-described in very preterm (VPT; born <32 weeks' gestation) infants with and without brain injury. We recruited 107 VPT infants - including 55 with brain injury (grade III-IV intraventricular hemorrhage, cystic periventricular leukomalacia, post-hemorrhagic hydrocephalus) - and collected FC data at/near term-equivalent age (35-45 weeks postmenstrual age). Correlation coefficients were used to calculate the FC between bilateral motor and visual cortices and thalami. At two years corrected-age, motor outcomes were assessed with the Bayley Scales of Infant and Toddler Development, 3rd edition. Multiple imputation was used to estimate missing data, and regression models related FC measures to motor outcomes. Within the brain-injured group only, interhemispheric motor cortex FC was positively related to gross motor outcomes. Thalamocortical and visual FC were not related to motor scores. This suggests neonatal alterations in motor system FC may provide prognostic information about impairments in children with brain injury.
Identifiants
pubmed: 36451363
pii: S2213-1582(22)00325-4
doi: 10.1016/j.nicl.2022.103260
pmc: PMC9668638
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103260Subventions
Organisme : NICHD NIH HHS
ID : F30 HD104313
Pays : United States
Organisme : NICHD NIH HHS
ID : F30 HD105336
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH122735
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103525
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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