Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients.
Aged
Aged, 80 and over
Humans
Angiotensin Receptor Antagonists
/ therapeutic use
Angiotensin-Converting Enzyme Inhibitors
/ therapeutic use
Angiotensins
/ therapeutic use
Antihypertensive Agents
/ therapeutic use
Calcium Channel Blockers
/ therapeutic use
Hypertension
/ drug therapy
Prospective Studies
Sodium Chloride Symporter Inhibitors
/ adverse effects
antihypertensive drugs
cardiovascular events
hypertension
older patients
survival
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
revised:
20
11
2022
received:
26
08
2022
accepted:
29
11
2022
pubmed:
2
12
2022
medline:
15
3
2023
entrez:
1
12
2022
Statut:
ppublish
Résumé
Hypertension management in older patients represents a challenge, particularly when hospitalized. The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge. Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death. Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.
Sections du résumé
BACKGROUND
BACKGROUND
Hypertension management in older patients represents a challenge, particularly when hospitalized.
OBJECTIVE
OBJECTIVE
The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients.
METHODS
METHODS
A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge.
RESULTS
RESULTS
Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death.
CONCLUSIONS
CONCLUSIONS
Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.
Substances chimiques
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Angiotensins
0
Antihypertensive Agents
0
Calcium Channel Blockers
0
Sodium Chloride Symporter Inhibitors
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13931Subventions
Organisme : Pfizer
Investigateurs
Pier Mannuccio Mannucci
(PM)
Alessandro Nobili
(A)
Giorgio Sesti
(G)
Antonello Pietrangelo
(A)
Francesco Perticone
(F)
Francesco Violi
(F)
Gino Roberto Corazza
(GR)
Salvatore Corrao
(S)
Alessandra Marengoni
(A)
Francesco Salerno
(F)
Matteo Cesari
(M)
Mauro Tettamanti
(M)
Luca Pasina
(L)
Carlotta Franchi
(C)
Carlotta Franchi
(C)
Alessio Novella
(A)
Mauro Tettamanti
(M)
Gabriella Miglio
(G)
Mauro Tettamanti
(M)
Alessia Antonella Galbussera
(AA)
Ilaria Ardoino
(I)
Alessio Novella
(A)
Domenico Prisco
(D)
Elena Silvestri
(E)
Giacomo Emmi
(G)
Alessandra Bettiol
(A)
Irene Mattioli
(I)
Gianni Biolo
(G)
Michela Zanetti
(M)
Giacomo Bartelloni
(G)
Michele Zaccari
(M)
Massimiliano Chiuch
(M)
Massimo Vanoli
(M)
Giulia Grignani
(G)
Edoardo Alessandro Pulixi
(EA)
Matteo Pirro
(M)
Graziana Lupattelli
(G)
Vanessa Bianconi
(V)
Riccardo Alcidi
(R)
Alessia Giotta
(A)
Massimo R Mannarino
(MR)
Domenico Girelli
(D)
Fabiana Busti
(F)
Giacomo Marchi
(G)
Mario Barbagallo
(M)
Ligia Dominguez
(L)
Vincenza Beneduce
(V)
Federica Cacioppo
(F)
Salvatore Corrao
(S)
Giuseppe Natoli
(G)
Salvatore Mularo
(S)
Massimo Raspanti
(M)
Christiano Argano
(C)
Federica Cavallaro
(F)
Marco Zoli
(M)
Maria Laura Matacena
(ML)
Giuseppe Orio
(G)
Eleonora Magnolfi
(E)
Giovanni Serafini
(G)
Angelo Simili
(A)
Mattia Brunori
(M)
Ilaria Lazzari
(I)
Angelo Simili
(A)
Maria Domenica Cappellini
(MD)
Giovanna Fabio
(G)
Margherita Migone De Amicis
(MM)
Giacomo De Luca
(G)
Natalia Scaramellini
(N)
Valeria Di Stefano
(V)
Simona Leoni
(S)
Sonia Seghezzi
(S)
Alessandra Danuto Di Mauro
(AD)
Diletta Maira
(D)
Marta Mancarella
(M)
Tiziano Lucchi
(T)
Paolo Dionigi Rossi
(PD)
Marta Clerici
(M)
Simona Leoni
(S)
Alessandra Danuta Di Mauro
(AD)
Giulia Bonini
(G)
Federica Conti
(F)
Silvia Prolo
(S)
Maddalena Fabrizi
(M)
Miriana Martelengo
(M)
Giulia Vigani
(G)
Antonio Di Sabatino
(A)
Emanuela Miceli
(E)
Marco Vincenzo Lenti
(MV)
Martina Pisati
(M)
Lavinia Pitotti
(L)
Donatella Padula
(D)
Valentina Antoci
(V)
Ginevra Cambiè
(G)
Roberto Pontremoli
(R)
Valentina Beccati
(V)
Giulia Nobili
(G)
Giovanna Leoncini
(G)
Jacopo Alberto
(J)
Federico Cattaneo
(F)
Luigi Anastasio
(L)
Lucia Sofia
(L)
Maria Carbone
(M)
Francesco Cipollone
(F)
Maria Teresa Guagnano
(MT)
Ilaria Rossi
(I)
Emanuele Valeriani
(E)
Damiani D'Ardes
(D)
Lucia Esposito
(L)
Simona Sestili
(S)
Ermanno Angelucci
(E)
Gerardo Mancuso
(G)
Daniela Calipari
(D)
Mosè Bartone
(M)
Giuseppe Delitala
(G)
Maria Berria
(M)
Alessandro Delitala
(A)
Maurizio Muscaritoli
(M)
Alessio Molfino
(A)
Enrico Petrillo
(E)
Antonella Giorgi
(A)
Christian Gracin
(C)
Giovanni Imbimbo
(G)
Giuseppe Zuccalà
(G)
Gabriella D'Aurizio
(G)
Giuseppe Romanelli
(G)
Alessandra Marengoni
(A)
Andrea Volpini
(A)
Daniela Lucente
(D)
Francesca Manzoni
(F)
Annalisa Pirozzi
(A)
Alberto Zucchelli
(A)
Antonio Picardi
(A)
Umberto Vespasiani Gentilucci
(UV)
Paolo Gallo
(P)
Chiara Dell'Unto
(C)
Giuseppe Bellelli
(G)
Maurizio Corsi
(M)
Cesare Antonucci
(C)
Chiara Sidoli
(C)
Giulia Principato
(G)
Alessandra Bonfanti
(A)
Hajnalka Szabo
(H)
Paolo Mazzola
(P)
Andrea Piazzoli
(A)
Maurizio Corsi
(M)
Franco Arturi
(F)
Elena Succurro
(E)
Bruno Tassone
(B)
Federica Giofrè
(F)
Maria Grazia Serra
(MG)
Maria Antonietta Bleve
(MA)
Antonio Brucato
(A)
Teresa De Falco
(T)
Enrica Negro
(E)
Martino Brenna
(M)
Lucia Trotta
(L)
Giovanni Lorenzo Squintani
(GL)
Maria Luisa Randi
(ML)
Fabrizio Fabris
(F)
Irene Bertozzi
(I)
Giulia Bogoni
(G)
Maria Victoria Rabuini
(MV)
Tancredi Prandini
(T)
Francesco Ratti
(F)
Chiara Zurlo
(C)
Lorenzo Cerruti
(L)
Elisabetta Cosi
(E)
Roberto Manfredini
(R)
Fabio Fabbian
(F)
Benedetta Boari
(B)
Alfredo De Giorgi
(A)
Ruana Tiseo
(R)
Giuseppe Paolisso
(G)
Maria Rosaria Rizzo
(MR)
Claudia Catalano
(C)
Irene Di Meo
(I)
Claudio Borghi
(C)
Enrico Strocchi
(E)
Eugenia Ianniello
(E)
Mario Soldati
(M)
Silvia Schiavone
(S)
Alessio Bragagni
(A)
Francesca Giulia Leoni
(FG)
Valeria De Sando
(V)
Sara Scarduelli
(S)
Michela Cammarosano
(M)
Ilenia Pareo
(I)
Carlo Sabbà
(C)
Francesco Saverio Vella
(FS)
Patrizia Suppressa
(P)
Giovanni Michele De Vincenzo
(GM)
Alessio Comitangelo
(A)
Emanuele Amoruso
(E)
Carlo Custodero
(C)
Giuseppe Re
(G)
Andrea Schilardi
(A)
Francesca Loparco
(F)
Luigi Fenoglio
(L)
Andrea Falcetta
(A)
Alessia Valentina Giraudo
(AV)
Salvatore D'Aniano
(S)
Anna L Fracanzani
(AL)
Silvia Tiraboschi
(S)
Annalisa Cespiati
(A)
Giovanna Oberti
(G)
Giordano Sigon
(G)
Felice Cinque
(F)
Flora Peyvandi
(F)
Raffaella Rossio
(R)
Giulia Colombo
(G)
Pasquale Agosti
(P)
Erica Pagliaro
(E)
Eleonora Semproni
(E)
Canetta Ciro
(C)
Valter Monzani
(V)
Valeria Savojardo
(V)
Giuliana Ceriani
(G)
Christian Folli
(C)
Francesco Salerno
(F)
Giada Pallini
(G)
Fabrizio Montecucco
(F)
Luciano Ottonello
(L)
Lara Caserza
(L)
Giulia Vischi
(G)
Salam Kassem
(S)
Luca Liberale
(L)
Nicola Lucio Liberato
(NL)
Tiziana Tognin
(T)
Francesco Purrello
(F)
Antonino Di Pino
(A)
Salvatore Piro
(S)
Renzo Rozzini
(R)
Lina Falanga
(L)
Maria Stella Pisciotta
(MS)
Francesco Baffa Bellucci
(FB)
Stefano Buffelli
(S)
Camillo Ferrandina
(C)
Francesca Mazzeo
(F)
Elena Spazzini
(E)
Giulia Cono
(G)
Giulia Cesaroni
(G)
Giuseppe Montrucchio
(G)
Paolo Peasso
(P)
Edoardo Favale
(E)
Cesare Poletto
(C)
Carl Margaria
(C)
Maura Sanino
(M)
Francesco Violi
(F)
Ludovica Perri
(L)
Luigina Guasti
(L)
Francesca Rotunno
(F)
Luana Castiglioni
(L)
Andrea Maresca
(A)
Alessandro Squizzato
(A)
Leonardo Campiotti
(L)
Alessandra Grossi
(A)
Roberto Davide Diprizio
(RD)
Francesco Dentali
(F)
Marco Bertolotti
(M)
Chiara Mussi
(C)
Giulia Lancellotti
(G)
Maria Vittoria Libbra
(MV)
Matteo Galassi
(M)
Yasmine Grassi
(Y)
Alessio Greco
(A)
Elena Bigi
(E)
Elisa Pellegrini
(E)
Laura Orlandi
(L)
Giulia Dondi
(G)
Lucia Carulli
(L)
Angela Sciacqua
(A)
Maria Perticone
(M)
Rosa Battaglia
(R)
Raffaele Maio
(R)
Aleandra Scozzafava
(A)
Valentino Condoleo
(V)
Tania Falbo
(T)
Lidia Colangelo
(L)
Marco Filice
(M)
Elvira Clausi
(E)
Vincenzo Stanghellini
(V)
Eugenio Ruggeri
(E)
Sara Del Vecchio
(S)
Ilaria Benzoni
(I)
Andrea Salvi
(A)
Roberto Leonardi
(R)
Giampaolo Damiani
(G)
Gianluca Moroncini
(G)
William Capeci
(W)
Massimo Mattioli
(M)
Giuseppe Pio Martino
(GP)
Lorenzo Biondi
(L)
Pietro Pettinari
(P)
Monica Ormas
(M)
Emanuele Filippini
(E)
Devis Benfaremo
(D)
Roberto Romiti
(R)
Riccardo Ghio
(R)
Anna Dal Col
(AD)
Salvatore Minisola
(S)
Luciano Colangelo
(L)
Mirella Cilli
(M)
Giancarlo Labbadia
(G)
Antonella Afeltra
(A)
Benedetta Marigliano
(B)
Maria Elena Pipita
(ME)
Pietro Castellino
(P)
Luca Zanoli
(L)
Alfio Gennaro
(A)
Agostino Gaudio
(A)
Samuele Pignataro
(S)
Francesca Mete
(F)
Miriam Gino
(M)
Guido Moreo
(G)
Silvia Prolo
(S)
Gloria Pina
(G)
Alberto Ballestrero
(A)
Fabio Ferrando
(F)
Roberta Gonella
(R)
Domenico Cerminara
(D)
Paolo Setti
(P)
Chiara Traversa
(C)
Camilla Scarsi
(C)
Bruno Graziella
(B)
Stefano Baldassarre
(S)
Salvatore Fragapani
(S)
Gabriella Gruden
(G)
Franco Berti
(F)
Giuseppe Famularo
(G)
Patrizia Tarsitani
(P)
Roberto Castello
(R)
Michela Pasino
(M)
Marcello Giuseppe Maggio Gian Paolo Ceda
(MGMGP)
Simonetta Morganti
(S)
Andrea Artoni
(A)
Margherita Grossi
(M)
Stefano Del Giacco
(S)
Davide Firinu
(D)
Giulia Costanzo
(G)
Giacomo Argiolas
(G)
Giovanni Paoletti
(G)
Francesca Losa
(F)
Giuseppe Montalto
(G)
Anna Licata
(A)
Filippo Alessandro Montalto
(FA)
Francesco Corica
(F)
Giorgio Basile
(G)
Antonino Catalano
(A)
Federica Bellone
(F)
Concetto Principato
(C)
Lorenzo Malatino
(L)
Benedetta Stancanelli
(B)
Valentina Terranova
(V)
Salvatore Di Marca
(S)
Rosario Di Quattro
(R)
Lara La Malfa
(L)
Rossella Caruso
(R)
Patrizia Mecocci
(P)
Carmelinda Ruggiero
(C)
Virginia Boccardi
(V)
Tiziana Meschi
(T)
Andrea Ticinesi
(A)
Antonio Nouvenne
(A)
Pietro Minuz
(P)
Luigi Fondrieschi
(L)
Giandomenico Nigro Imperiale
(GN)
Sarah Morellini
(S)
Mario Pirisi
(M)
Gian Paolo Fra
(GP)
Daniele Sola
(D)
Mattia Bellan
(M)
Roberto Quadri
(R)
Erica Larovere
(E)
Marco Novelli
(M)
Emilio Simeone
(E)
Rosa Scurti
(R)
Fabio Tolloso
(F)
Roberto Tarquini
(R)
Alice Valoriani
(A)
Silvia Dolenti
(S)
Giulia Vannini
(G)
Riccardo Volpi
(R)
Pietro Bocchi
(P)
Alessandro Vignali
(A)
Sergio Harari
(S)
Chiara Lonati
(C)
Federico Napoli
(F)
Italia Aiello
(I)
Francesco Purrello
(F)
Antonino Di Pino
(A)
Teresa Salvatore
(T)
Lucio Monaco
(L)
Carmen Ricozzi
(C)
Alberto Pilotto
(A)
Ilaria Indiano
(I)
Federica Gandolfo
(F)
Franco Laghi Pasini
(FL)
Pier Leopoldo Capecchi
(PL)
Ranuccio Nuti
(R)
Roberto Valenti
(R)
Martina Ruvio
(M)
Silvia Cappelli
(S)
Alberto Palazzuoli
(A)
Mauro Bernardi
(M)
Silvia Li Bassi
(SL)
Luca Santi
(L)
Giacomo Zaccherini
(G)
Vittorio Durante
(V)
Daniela Tirotta
(D)
Giovanna Eusebi
(G)
Marco Cattaneo
(M)
Maria Valentina Amoruso
(MV)
Paola Fracasso
(P)
Cristina Fasolino
(C)
Moreno Tresoldi
(M)
Enrica Bozzolo
(E)
Sarah Damanti
(S)
Massimo Porta
(M)
Miriam Gino
(M)
Giuseppe Armentaro
(G)
Maria Immacolata Arnone
(MI)
Milena Barone
(M)
Lorenzo Bertolino
(L)
Sara Bianco
(S)
Nicolò Binello
(N)
Simona Brancati
(S)
Agostino Buonauro
(A)
Elena Buzzetti
(E)
William Capeci
(W)
Federica Caradio
(F)
Sebastiano Cicco
(S)
Antonio Cimellaro
(A)
William Cordeddu
(W)
Rosa Curcio
(R)
Andrea Dalbeni
(A)
Marco D'Abbondanza
(M)
Salvatore D'Agnano
(S)
Damiano D'Ardes
(D)
Martina De Feo
(M)
Salvatore Di Marca
(S)
Emilia Donnarumma
(E)
Marco Fei
(M)
Emanuele Filippini
(E)
Carmine Gabriele Gambino
(CG)
Paolo Giorgini
(P)
Rosa Lombardi
(R)
Alberto Maria Marra
(AM)
Massimo Mattioli
(M)
Giuseppe Miceli
(G)
Paola Naccarato
(P)
Silvia Noviello
(S)
Gaia Olivieri
(G)
Donatella Padula
(D)
Roberta Parente
(R)
Chiara Pes
(C)
Salvatore Piano
(S)
Francesca Serena Pignataro
(FS)
Sonia Poma
(S)
Enrica Porceddu
(E)
Giacomo Pucci
(G)
Marco Ricchio
(M)
Anna Sabena
(A)
Marco Salice
(M)
Andrea Salzano
(A)
Claudia Santarossa
(C)
Ambra Savona
(A)
Caterina Savrié
(C)
Roberto Scicali
(R)
Mario Stabile
(M)
Giovanni Talerico
(G)
Michela Talia
(M)
Eliezer Joseph Tassone
(EJ)
Thomas Teatini
(T)
Elisabetta Tombolini
(E)
Matteo Traversa
(M)
Elia Vettore
(E)
Alessandro Vignal
(A)
Luca Vilardi
(L)
Rosanna Villani
(R)
Francesco Vitale
(F)
Pier Mannuccio Mannucci
(PM)
Alessandro Nobili
(A)
Giorgio Sesti
(G)
Antonello Pietrangelo
(A)
Francesco Perticone
(F)
Francesco Violi
(F)
Gino Roberto Corazza
(GR)
Salvatore Corrao
(S)
Alessandra Marengoni
(A)
Francesco Salerno
(F)
Matteo Cesari
(M)
Mauro Tettamanti
(M)
Luca Pasina
(L)
Carlotta Franchi
(C)
Carlotta Franchi
(C)
Alessio Novella
(A)
Mauro Tettamanti
(M)
Gabriella Miglio
(G)
Mauro Tettamanti
(M)
Alessia Antonella Galbussera
(AA)
Ilaria Ardoino
(I)
Alessio Novella
(A)
Domenico Prisco
(D)
Elena Silvestri
(E)
Giacomo Emmi
(G)
Alessandra Bettiol
(A)
Irene Mattioli
(I)
Gianni Biolo
(G)
Michela Zanetti
(M)
Giacomo Bartelloni
(G)
Michele Zaccari
(M)
Massimiliano Chiuch
(M)
Massimo Vanoli
(M)
Giulia Grignani
(G)
Edoardo Alessandro Pulixi
(EA)
Matteo Pirro
(M)
Graziana Lupattelli
(G)
Vanessa Bianconi
(V)
Riccardo Alcidi
(R)
Alessia Giotta
(A)
Massimo R Mannarino
(MR)
Domenico Girelli
(D)
Fabiana Busti
(F)
Giacomo Marchi
(G)
Mario Barbagallo
(M)
Ligia Dominguez
(L)
Vincenza Beneduce
(V)
Federica Cacioppo
(F)
Salvatore Corrao
(S)
Giuseppe Natoli
(G)
Salvatore Mularo
(S)
Massimo Raspanti
(M)
Christiano Argano
(C)
Federica Cavallaro
(F)
Marco Zoli
(M)
Maria Laura Matacena
(ML)
Giuseppe Orio
(G)
Eleonora Magnolfi
(E)
Giovanni Serafini
(G)
Angelo Simili
(A)
Mattia Brunori
(M)
Ilaria Lazzari
(I)
Angelo Simili
(A)
Maria Domenica Cappellini
(MD)
Giovanna Fabio
(G)
Margherita Migone De Amicis
(MM)
Giacomo De Luca
(G)
Natalia Scaramellini
(N)
Valeria Di Stefano
(V)
Simona Leoni
(S)
Sonia Seghezzi
(S)
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Informations de copyright
© 2022 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
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