Active DNA demethylation damages DNA.

DNA Demethylation Macrophages / metabolism Neurons / metabolism Enhancer Elements, Genetic Humans DNA Breaks, Single-Stranded

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
02 12 2022
Historique:
entrez: 1 12 2022
pubmed: 2 12 2022
medline: 6 12 2022
Statut: ppublish

Résumé

Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage DNA.

Identifiants

DOI: 10.1126/science.adf3171 PMID: 36454845 PMC: PMC10686637
pubmed: 36454845
doi: 10.1126/science.adf3171
pmc: PMC10686637
mid: NIHMS1943240
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

948-949

Subventions

Organisme : NCI NIH HHS
ID : R35 CA210043
Pays : United States

Commentaires et corrections

Type : CommentOn

Références

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pubmed: 36454826
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pubmed: 31324781
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pubmed: 21722948
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pubmed: 36163278
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pubmed: 24529596
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pubmed: 25280211

Auteurs

Isaac F López-Moyado (IF)

Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA.
Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.

Anjana Rao (A)

Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA.
Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Désalkylation › Déméthylation › Déméthylation de l'ADN › Active DNA demethylation damages DNA.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Active DNA demethylation damages DNA.
questionsmedicales.fr › Cellules › Neurones › Active DNA demethylation damages DNA.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Active DNA demethylation damages DNA.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Active DNA demethylation damages DNA.
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Cassures de l'ADN › Cassures simple-brin de l'ADN › Active DNA demethylation damages DNA.