Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.
DCC receptors
Guidance cues
In vivo microdialysis cocaine
Netrin-1
Place preference
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
20
09
2022
accepted:
23
11
2022
pubmed:
6
12
2022
medline:
17
2
2023
entrez:
5
12
2022
Statut:
ppublish
Résumé
The Netrin-1/DCC guidance cue pathway is critically involved in the adolescent organization of the mesocorticolimbic dopamine circuitry. Adult mice heterozygous for Dcc show reduced dopamine release in the nucleus accumbens in response to amphetamine and, in turn, blunted sensitivity to the rewarding effects of this drug. Here, we tested whether the protective effects of Dcc haploinsufficiency are specific to stimulant drugs of abuse or instead extrapolate to opioids and ethanol. We used the place preference paradigm to measure the rewarding effects of cocaine (20 mg/kg), morphine (5 or 10 mg/Kg), or ethanol (20%) in adult (PND 75) male Dcc haploinsufficient mice or their wild-type litter mates. In a second experiment, we compared in these two genotypes, in vivo dopamine release in the nucleus accumbens after a single i.p. injection of morphine (10 mg/kg). We found reduced morphine-induced dopamine release in the nucleus accumbens of Dcc haploinsufficient male mice, but, contrary to the effects of stimulant drugs, there is no effect of genotype on morphine-induced conditioned preference. These findings show that reduced drug-induced mesolimbic dopamine in Dcc haploinsufficient male mice protects specifically against the rewarding effects of stimulant drugs, but not against the rewarding properties of morphine and ethanol. These results suggest that these drugs exert their rewarding effect via different brain circuits.
Identifiants
pubmed: 36471064
doi: 10.1007/s00213-022-06288-1
pii: 10.1007/s00213-022-06288-1
pmc: PMC10296775
mid: NIHMS1907722
doi:
Substances chimiques
Cocaine
I5Y540LHVR
Dopamine
VTD58H1Z2X
DCC Receptor
0
Morphine
76I7G6D29C
Tumor Suppressor Proteins
0
Ethanol
3K9958V90M
Receptors, Cell Surface
0
Dcc protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-646Subventions
Organisme : NIDA NIH HHS
ID : P50 DA005010
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA048796
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA037911
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA037911
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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