Highly Water-Soluble Cucurbit[8]uril Derivative as a Broad-Spectrum Neuromuscular Block Reversal Agent.

Neuromuscular Nondepolarizing Agents / therapeutic use gamma-Cyclodextrins / pharmacology Neuromuscular Blockade Water

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 12 2022
Historique:
pubmed: 9 12 2022
medline: 24 12 2022
entrez: 8 12 2022
Statut: ppublish

Résumé

Broad-spectrum agents for the reversal of residual curarization induced by neuromuscular blocking agents are of great significance. Here, we report a highly water-soluble cucurbit[8]uril (CB[8]) derivative as a broad-spectrum neuromuscular block reversal agent induced by both benzylisquinolinium and aminosteroid neuromuscular block agents by the supramolecular sequestration strategy. The UV/Vis competition titration assays suggest the high binding affinity of the CB[8] derivative toward both benzylisquinolinium-type cisatracurium besylate and aminosteroid-type rocuronium, vecuronium, and pancuronium, at the level of 10

Identifiants

DOI: 10.1021/acs.jmedchem.2c01677 PMID: 36480913
pubmed: 36480913
doi: 10.1021/acs.jmedchem.2c01677
doi:

Substances chimiques

Neuromuscular Nondepolarizing Agents 0
gamma-Cyclodextrins 0
Water 059QF0KO0R
cucurbit(8)uril 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16893-16901

Auteurs

Hong-Kun Liu (HK)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.

Furong Lin (F)

Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Shang-Bo Yu (SB)

Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Yan Wu (Y)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.

Shuai Lu (S)

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, P.R. China.

Yue-Yang Liu (YY)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.

Qiao-Yan Qi (QY)

Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Jin Cao (J)

Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Wei Zhou (W)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.

Xiaopeng Li (X)

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, P.R. China.
ORCID: 0000-0001-9655-9551

Hui Wang (H)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.

Dan-Wei Zhang (DW)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.
ORCID: 0000-0003-1244-1850

Zhan-Ting Li (ZT)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.
Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
ORCID: 0000-0003-3954-0015

Da Ma (D)

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China.
ORCID: 0000-0002-5300-7500

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents du système nerveux périphérique › Agents neuromusculaires › Curarisants › Curarisants non dépolarisants › Highly Water-Soluble Cucurbit[8]uril...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Cyclodextrines gamma › Highly Water-Soluble Cucurbit[8]uril...
questionsmedicales.fr › Techniques d'investigation › Blocage neuromusculaire › Highly Water-Soluble Cucurbit[8]uril...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Highly Water-Soluble Cucurbit[8]uril...