Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Childhood obesity
Glucose metabolism
Insulin sensitivity
Overweight
Thyroid hormone
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
05
11
2022
accepted:
28
11
2022
medline:
1
5
2023
pubmed:
10
12
2022
entrez:
9
12
2022
Statut:
ppublish
Résumé
An alteration of central and peripheral sensitivity to thyroid hormones (THs) seems to be associated with an increased risk of prediabetes in adulthood. Aims of this study was to evaluate the relationship between the sensitivity to THs, the severity of overweight and the glyco-metabolic alterations in prepubertal euthyroid children with obesity. Prepubertal subjects with simple obesity and matched controls were recruited from three Italian pediatric endocrinology centers and underwent clinical and biochemical evaluations. HOMA-IR, HOMA-β, insulinogenic index, Matsuda index were evaluated in children with obesity. Indexes of peripheral sensitivity (FT3/FT4 ratio) and central sensitivity (TSH index, TSHI; TSH T4 resistance index, TT4RI; Thyroid Feedback Quantile-based Index, TFQI; Parametric TFQI, PTFQI) to thyroid hormones were calculated in both groups. Eighty prepubertal children with obesity (Group 1; mean age 7.60 ± 1.51 years) and 28 healthy normal-weight controls (Group 2) were recruited. BMI and leptin were higher in group 1 than in group 2. The FT3/FT4 ratio correlated negatively with HOMA-β (r = -0.29; p = 0.01) and was significantly positively associated with BMI (p = 0.03), IR (p = 0.03) and fasting blood glucose (p = 0.04) in group 1. TT4RI, TSHI, PTFQI, TFQI, were significantly negatively associated with Matsuda-index, IGI and BMI in group 1. Central and peripheral sensitivity to thyroid hormones is significantly affected by the severity of overweight and the presence of IR. Altered tissue sensitivity to THs in the prepubertal children with obesity could be implicated in the pathogenesis of glucose metabolism impairment.
Identifiants
pubmed: 36484935
doi: 10.1007/s12020-022-03276-5
pii: 10.1007/s12020-022-03276-5
doi:
Substances chimiques
Thyroid Hormones
0
Thyrotropin
9002-71-5
Glucose
IY9XDZ35W2
Thyroxine
Q51BO43MG4
Triiodothyronine
06LU7C9H1V
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
308-311Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
F. Santini, P. Marzullo, M. Rotondi, G. Ceccarini, L. Pagano, S. Ippolito, L. Chiovato, B. Biondi, Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease. Eur. J. Endocrinol. 171, R137–R152 (2014). https://doi.org/10.1530/EJE-14-0067
doi: 10.1530/EJE-14-0067
pubmed: 25214234
V. Calcaterra, G. Biganzoli, S. Ferraro, A. Mari, A. Mandelli, V. Fabiano, P. Carlucci, G. Pelizzo, E. Zoia, G. Lanfranchi, et al. Thyroid Function and Metabolic Syndrome in Children and Adolescents with Neuromotor Disability. Children (Basel) 9, (2022). https://doi.org/10.3390/children9101531 .
A. Chatzitomaris, R. Hoermann, J.E. Midgley, S. Hering, A. Urban, B. Dietrich, A. Abood, H.H. Klein, J.W. Dietrich, Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming. Front. Endocrinol. (Lausanne) 8, 163 (2017). https://doi.org/10.3389/fendo.2017.00163
doi: 10.3389/fendo.2017.00163
pubmed: 28775711
L.C. Fontenelle, M.M. Feitosa, J.S. Severo, T.E. Freitas, J.B. Morais, F.L. Torres-Leal, G.S. Henriques, D. do Nascimento Marreiro, Thyroid Function in Human Obesity: Underlying Mechanisms. Horm. Metab. Res. 48, 787–794 (2016). https://doi.org/10.1055/s-0042-121421
doi: 10.1055/s-0042-121421
pubmed: 27923249
A. Tropeano, D. Corica, S. Curatola, A. Li Pomi, C. Casto, A. Alibrandi, G. Pepe, T. Aversa, M. Wasniewska, The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children. J. Endocrinol. Investig. (2022), https://doi.org/10.1007/s40618-022-01899-z
M. Laclaustra, B. Moreno-Franco, J.M. Lou-Bonafonte, R. Mateo-Gallego, J.A. Casasnovas, P. Guallar-Castillon, A. Cenarro, F. Civeira, Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome. Diabetes Care 42, 303–310 (2019). https://doi.org/10.2337/dc18-1410
doi: 10.2337/dc18-1410
pubmed: 30552134
B. Liu, Z. Wang, J. Fu, H. Guan, Z. Lyu, W. Wang, Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study. Front. Endocrinol. (Lausanne) 12, 657114 (2021). https://doi.org/10.3389/fendo.2021.657114
doi: 10.3389/fendo.2021.657114
pubmed: 34017311
D. Corica, L. Oreto, G. Pepe, M.P. Calabro, L. Longobardo, L. Morabito, G.B. Pajno, A. Alibrandi, T. Aversa, M. Wasniewska, Precocious Preclinical Cardiovascular Sonographic Markers in Metabolically Healthy and Unhealthy Childhood Obesity. Front. Endocrinol. (Lausanne) 11, 56 (2020). https://doi.org/10.3389/fendo.2020.00056
doi: 10.3389/fendo.2020.00056
pubmed: 32194501
pmcid: 7062712
D. Corica, C. Zusi, F. Olivieri, M. Marigliano, C. Piona, E. Fornari, A. Morandi, M. Corradi, E. Miraglia Del Giudice, D. Gatti et al. Vitamin D affects insulin sensitivity and beta-cell function in obese non-diabetic youths. Eur. J. Endocrinol. 181, 439–450 (2019). https://doi.org/10.1530/EJE-19-0369
doi: 10.1530/EJE-19-0369
pubmed: 31408845
G. Valerio, M.R. Licenziati, A. Iannuzzi, A. Franzese, P. Siani, G. Riccardi, P. Rubba, Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr. Metab. Cardiovasc. Dis. 16, 279–284 (2006). https://doi.org/10.1016/j.numecd.2005.12.007
doi: 10.1016/j.numecd.2005.12.007
pubmed: 16679220
Y.J. Zhang, W. Zhao, M.Y. Zhu, S.S. Tang, H. Zhang, Thyroid-stimulating hormone induces the secretion of tumor necrosis factor-alpha from 3T3-L1 adipocytes via a protein kinase A-dependent pathway. Exp. Clin. Endocrinol. Diabetes 121, 488–493 (2013). https://doi.org/10.1055/s-0033-1347266
doi: 10.1055/s-0033-1347266
pubmed: 23864495