The mouse claustrum synaptically connects cortical network motifs.
CP: Neuroscience
attention
circuit
cognition
cognitive control
default mode
frontoparietal
optogenetics
salience
task-positive
working memory
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
20 12 2022
20 12 2022
Historique:
received:
15
06
2022
revised:
31
10
2022
accepted:
30
11
2022
entrez:
21
12
2022
pubmed:
22
12
2022
medline:
24
12
2022
Statut:
ppublish
Résumé
Spatially distant areas of the cerebral cortex coordinate their activity into networks that are integral to cognitive processing. A common structural motif of cortical networks is co-activation of frontal and posterior cortical regions. The neural circuit mechanisms underlying such widespread inter-areal cortical coordination are unclear. Using a discovery based functional magnetic resonance imaging (fMRI) approach in mouse, we observe frontal and posterior cortical regions that demonstrate significant functional connectivity with the subcortical nucleus, the claustrum. Examining whether the claustrum synaptically supports such frontoposterior cortical network architecture, we observe cortico-claustro-cortical circuits reflecting the fMRI data: significant trans-claustral synaptic connectivity from frontal cortices to posteriorly lying sensory and sensory association cortices contralaterally. These data reveal discrete cortical pathways through the claustrum that are positioned to support cortical network motifs central to cognitive control functions and add to the canon of major extended cortico-subcortico-cortical systems in the mammalian brain.
Identifiants
pubmed: 36543121
pii: S2211-1247(22)01756-9
doi: 10.1016/j.celrep.2022.111860
pmc: PMC9838879
mid: NIHMS1860007
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111860Subventions
Organisme : NIMH NIH HHS
ID : F31 MH126465
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024845
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA028070
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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