Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca
Ca2+ mobilization
Notch3
renal haemodynamics
renal resistance vessels
vasoreactivity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Dec 2022
16 Dec 2022
Historique:
received:
19
10
2022
revised:
09
12
2022
accepted:
13
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Notch3 plays an important role in the differentiation and development of vascular smooth muscle cells. Mice lacking Notch3 show deficient renal autoregulation. The aim of the study was to investigate the mechanisms involved in the Notch3-mediated control of renal vascular response. To this end, renal resistance vessels (afferent arterioles) were isolated from Notch3
Identifiants
pubmed: 36555708
pii: ijms232416068
doi: 10.3390/ijms232416068
pmc: PMC9788231
pii:
doi:
Substances chimiques
Angiotensin II
11128-99-7
Calcium
SY7Q814VUP
Calcium Channel Blockers
0
Mibefradil
27B90X776A
Nifedipine
I9ZF7L6G2L
Notch3 protein, mouse
0
Receptor, Notch3
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Inserm
ID : recurring annual funding
Organisme : Sorbonne University
ID : recurring annual funding
Organisme : Western Norway Regional Health Authority
ID : Annual fund
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