Endothelial GLUTs and vascular biology.

Glucose / metabolism Glucose Transport Proteins, Facilitative / metabolism Biological Transport Glycolysis Biology
Endothelial cell Glucose transporter Metabolism Vascular biology

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Feb 2023
Historique:
received: 08 11 2022
revised: 15 12 2022
accepted: 21 12 2022
pubmed: 25 12 2022
medline: 19 1 2023
entrez: 24 12 2022
Statut: ppublish

Résumé

Endothelial metabolism is a promising target for vascular functional regulation and disease therapy. Glucose is the primary fuel for endothelial metabolism, supporting ATP generation and endothelial cell survival. Multiple studies have discussed the role of endothelial glucose catabolism, such as glycolysis and oxidative phosphorylation, in vascular functional remodeling. However, the role of the first gatekeepers of endothelial glucose utilization, glucose transporters, in the vasculature has long been neglected. Here, this review summarizes glucose transporter studies in vascular research. We mainly focus on GLUT1 and GLUT3 because they are the most critical glucose transporters responsible for most endothelial glucose uptake. Some interesting topics are also discussed, intending to provide directions for endothelial glucose transporter research in the future.

Identifiants

DOI: 10.1016/j.biopha.2022.114151 PMID: 36565587
pubmed: 36565587
pii: S0753-3322(22)01540-2
doi: 10.1016/j.biopha.2022.114151
pii:
doi:

Substances chimiques

Glucose IY9XDZ35W2
Glucose Transport Proteins, Facilitative 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114151

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Wan-Zhou Wu (WZ)

Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Center for Vascular Disease and Translational Medicine, Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.

Yong-Ping Bai (YP)

Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: baiyongping@csu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Endothelial GLUTs and vascular biology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de glucose par diffusion facilitée › Endothelial GLUTs and vascular biology.
questionsmedicales.fr › Métabolisme › Transport biologique › Endothelial GLUTs and vascular biology.
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Endothelial GLUTs and vascular biology.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Endothelial GLUTs and vascular biology.