Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model.
aging
decision making
neuroimaging
punishment
rat
risk taking
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
08
09
2022
revised:
07
12
2022
accepted:
13
12
2022
pubmed:
4
1
2023
medline:
17
1
2023
entrez:
3
1
2023
Statut:
epublish
Résumé
Altered decision making at advanced ages can have a significant impact on an individual's quality of life and the ability to maintain personal independence. Relative to young adults, older adults make less impulsive and less risky choices; although these changes in decision making could be considered beneficial, they can also lead to choices with potentially negative consequences (e.g., avoidance of medical procedures). Rodent models of decision making have been invaluable for dissecting cognitive and neurobiological mechanisms that contribute to age-related changes in decision making, but they have predominantly used costs related to timing or probability of reward delivery and have not considered other equally important costs, such as the risk of adverse consequences. The current study therefore used a rat model of decision making involving risk of explicit punishment to examine age-related changes in this form of choice behavior in male rats, and to identify potential cognitive and neurobiological mechanisms that contribute to these changes. Relative to young rats, aged rats displayed greater risk aversion, which was not attributable to reduced motivation for food, changes in shock sensitivity, or impaired cognitive flexibility. Functional MRI analyses revealed that, overall, functional connectivity was greater in aged rats compared with young rats, particularly among brain regions implicated in risky decision making such as basolateral amygdala, orbitofrontal cortex, and ventral tegmental area. Collectively, these findings are consistent with greater risk aversion found in older humans, and reveal age-related changes in brain connectivity.
Identifiants
pubmed: 36596593
pii: ENEURO.0385-22.2022
doi: 10.1523/ENEURO.0385-22.2022
pmc: PMC9840382
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : K99 DA041493
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG060778
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG061892
Pays : United States
Informations de copyright
Copyright © 2023 Orsini et al.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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